ArticleNutrition research and practice2018
Anti-neuroinflammatory effects of ethanolic extract of black chokeberry (
Article in Nutrition research and practice, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 23 citations in OpenAlex.
- Phytochemical Profile, Antioxidant Activity, and Anti-Neuroinflammatory Effects of a Novel Dry Extract of Libidibia ferrea in Microglial Cells.Chemistry & biodiversity · 2026Article
- A Comprehensive Review of the Functional Potential and Sustainable Applications ofPlants (Basel, Switzerland) · 2024Review
- Functional Activities and Mechanisms ofCurrent issues in molecular biology · 2024Review
- Quinic Acid Alleviates Behavior Impairment by Reducing Neuroinflammation and MAPK Activation in LPS-Treated Mice.Biomolecules & therapeutics · 2024Article
- The Efficacy of Black Chokeberry Fruits against Cardiovascular Diseases.International journal of molecular sciences · 2021Review
- Magnetic Ligand Fishing Using Immobilized Cyclooxygenase-2 for Identification and Screening of Anticoronary Heart Disease Ligands FromFrontiers in nutrition · 2021Article
- Evaluation of Antioxidant and Anti-Inflammatory Activity of Anthocyanin-Rich Water-Soluble Aronia Dry Extracts.Molecules (Basel, Switzerland) · 2020Article
- Effect of Korean Magnolia obovata Extract on Platelet-Derived Growth Factor-Induced Vascular Smooth Muscle Cells.Chinese journal of integrative medicine · 2020Article
- Therapeutic effect of Shinkiwhan, herbal medicine, regulates OPG/RANKL/RANK system on ovariectomy-induced bone loss rat.Physical activity and nutrition · 2020Article
- Effect of black chokeberry on skeletal muscle damage and neuronal cell death.Journal of exercise nutrition & biochemistry · 2019Article
- Smallanthus sonchifolius leaf attenuates neuroinflammation.Journal of exercise nutrition & biochemistry · 2018Article
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectivesOne of the mechanisms considered to be prevalent in the development of Alzheimer's disease (AD) is hyper-stimulation of microglia. Black chokeberry ( MATERIALS/
methodsWe undertook to assess the anti-inflammatory effect of the ethanolic extract of black chokeberry friut (BCE) in BV2 cells, and evaluate its neuroprotective effect in the lipopolysaccharide (LPS)-induced mouse model of AD.
resultsFollowing stimulation of BV2 cells by LPS, exposure to BCE significantly reduced the generation of nitric oxide as well as mRNA levels of numerous inflammatory factors such as inducible nitric oxide synthase (iNOS), cyclooxygenase 2 (COX-2), interleukin 1 beta (IL-1β), and tumor necrosis factor alpha (TNF-α). In addition, AD was induced in a mouse model by intraperitoneal injection of LPS (250 µg/kg), subsequent to which we investigated the neuroprotective effects of BCE (50 mg/kg) on brain damage. We observed that BCE significantly reduced tissue damage in the hippocampus by downregulating iNOS, COX-2, and TNF-α levels. We further identified the quinic acids in BCE using liquid chromatography-mass spectrometry (LCMS). Furthermore, we confirmed the neuroprotective effect of BCE and quinic acid on amyloid beta-induced cell death in rat hippocampal primary neurons.
conclusionsOur findings suggest that black chokeberry has protective effects against the development of AD.
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