ArticleWorld journal of hepatology2018
Predicting early outcomes of liver transplantation in young children: The EARLY study.
Article in World journal of hepatology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Pediatric and adult liver transplantation in Bahrain: The experiences in a country with no available liver transplant facilities.World journal of transplantation · 2024Article
- Mental health in children with living donor liver transplantation: a propensity score-matched analysis.Child and adolescent psychiatry and mental health · 2022Article
- Risk Factors Affecting Outcomes in Pediatric Liver Transplantation: A Real-World Single-Center Experience.Annals of transplantation · 2021Article
- Acute liver failure in newborns.Turkish archives of pediatrics · 2021Review
- Article
- Risk factors of hepatic artery thrombosis in pediatric deceased donor liver transplantation.Pediatric surgery international · 2019Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo determine potentially modifiable predictors of early outcomes after liver transplantation in children of age < 3 years.
methodsThis study was a retrospective chart review including all consecutive children of age less than 3-years-old having had a liver transplant done at the Western Canadian referral center from June 2005 to June 2015. Pre-specified potential predictor variables and primary and secondary outcomes were recorded using standard definitions and a case report form. Associations between potential predictor variables and outcomes were determined using univariate and multiple logistic [odds ratio (OR); 95%CI] or linear (effect size, ES; 95%CI) regressions.
resultsThere were 65 children, of mean age 11.9 (SD 7.1) mo and weight 8.5 (2.1) kg, with biliary-atresia in 40 (62%), who had a living related donor [LRD; 29 (45%)], split/reduced [21 (32%)] or whole liver graft [15 (23%)]. Outcomes after liver transplant included: ventilator-days of 12.5 (14.1); pediatric intensive care unit mortality of 5 (8%); re-operation in 33 (51%), hepatic artery thrombosis (HAT) in 12 (19%), portal vein thrombosis (PVT) in 11 (17%), and any severe complication (HAT, PVT, bile leak, bowel perforation, intraabdominal infection, retransplant, or death) in 32 (49%) patients. Predictors of the prespecified primary outcomes on multiple regression were: (1) HAT: split/reduced (OR 0.06; 0.01, 0.76;
conclusionIn young children, whole liver graft and surgeon was associated with more complications, and higher AT postoperative day 2-5 was associated with fewer complications early after liver transplantation.
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