ArticleWorld journal of hepatology2018
Preserved liver regeneration capacity after partial hepatectomy in rats with non-alcoholic steatohepatitis.
Article in World journal of hepatology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
- Hepatic Overexpression of a Novel Soluble Endogenous Transforming Growth Factor β Type II Receptor-Immunoglobulin G1 Fc Fusion Protein (TβRII-SE/Fc) Attenuates Early Stage Metabolic Dysfunction-Associated Steatotic Liver Disease in Rats.ACS pharmacology & translational science · 2026Article
- Enhanced surgical tolerance of schistosomiasis-induced fibrotic liver following treatment withWorld journal of hepatology · 2026Article
- Role of ammonia in NAFLD: An unusual suspect.JHEP reports : innovation in hepatology · 2023Review
- Utility of Human Relevant Preclinical Animal Models in Navigating NAFLD to MAFLD Paradigm.International journal of molecular sciences · 2022Review
- F4/80Molecules (Basel, Switzerland) · 2021Article
- Modeling Diet-Induced NAFLD and NASH in Rats: A Comprehensive Review.Biomedicines · 2021Review
- Mechanisms of nonalcoholic fatty liver disease and implications for surgery.Langenbeck's archives of surgery · 2021Review
- Role of interleukin 6 in liver cell regeneration after hemi-hepatectomy, correlation with liver enzymes and flow cytometric study.Clinical and experimental hepatology · 2020Article
- Efficacy of interleukin-6 in the induction of liver cell proliferation after hemi-hepatectomy: histopathologic and immunohistochemical study.International journal of clinical and experimental pathology · 2020Article
- Different Forms of Ursolic Acid and Their Effect on Liver Regeneration.Evidence-based complementary and alternative medicine : eCAM · 2020Article
- Optimized Ki-67 staining in murine cells: a tool to determine cell proliferation.Molecular biology reports · 2019Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo evaluate the liver regeneration capacity (LRC) after partial hepatectomy (PH) in experimental non-alcoholic steatohepatitis (NASH).
methodsFifty-four female rats were fed a high-fat, high-cholesterol diet (HFCD, 65% fat, 1% cholesterol) or standard diet (STD) for 16 wk. A 70% PH was performed and the animals were euthanised before PH or 2 or 5 d post-PH. LRC was evaluated using: The total number of Ki-67 positive hepatocytes in the caudate lobe, N(Ki-67, lobe) evaluated in a stereology-based design, the regenerated protein ratio (RPR), prothrombin-proconvertin ratio (PP), and mRNA expression of genes related to regeneration.
resultsThe HFCD NASH model showed significant steatosis with ballooning and inflammation, while no fibrosis was present. Mortality was similar in HFCD and STD animals following PH. HFCD groups were compared to respective STD groups and HFCD animals had a significantly elevated alanine transaminase at baseline (
conclusionNASH rats had a preserved LRC after hepatectomy when compared to STD rats. The methods and models of NASH are essential in understanding and evaluating LRC.
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