Evidence map›Paper›PMID 29399261›Full record

ArticleThe Journal of clinical and aesthetic dermatology2017

Hyaluronic Acid Sodium Salt 0.2% Gel in the Treatment of a Recalcitrant Distal Leg Ulcer: A Case Report.

Mario Tagliagambe, Tuan A Elstrom, Daniel B Ward

Open access · greenAbstract readCase Reports
PubMed Full text at PMC
In one paragraph

Article in The Journal of clinical and aesthetic dermatology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 2 countries.

Mario TagliagambeDr. Tagliagambe is a primary care physician at Adirondack Health in Saranac Lake, New York.
Tuan A ElstromDr. Tagliagambe is a primary care physician at Adirondack Health in Saranac Lake, New York.
Daniel B WardDr. Tagliagambe is a primary care physician at Adirondack Health in Saranac Lake, New York.
Adirondack Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Venous leg ulcers can lead to debilitation and a decrease in quality of life and can require costly treatments. Compression therapy remains the foundation of conservative treatment. However, some ulcers become indolent, chronic, and unresolved for years, even with adherence to standard of care. Here, the authors describe the case of a 56-year-old male patient with a recalcitrant recurrent distal leg ulcer. The ulcer was treated initially with debridement and compression therapy, respectively, and then subsequently with hyaluronic acid sodium salt 0.2% gel, which prompted complete wound closure. Hyaluronic acid is known to stimulate angiogenesis and exert fibrogenic action within inflamed and impaired healing tissues. Only a limited number of studies have been conducted to evaluate the clinical use of hyaluronic acid for treating venous leg ulcers. Success obtained with this patient should spur future clinical studies to fully evaluate this modality as a safe, efficacious, expeditious, and cost-effective option for the management of recalcitrant chronic ulcers.

Indexed as

gelhyaluronic acidtopicalVenous leg ulcerwound healing

Identifiers

PMID29399261
PMCPMC5774911
OpenAlexW2983368555

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.