Evidence map›Paper›PMID 29399212›Full record

ArticleThe open cardiovascular medicine journal2017

Insulin Sensitivity and Insulin Resistance in Non-Diabetic Middle-Aged Patients with Obstructive Sleep Apnoea Syndrome.

K Archontogeorgis, N Papanas, E Nena, A Tzouvelekis, C Tsigalou, A Voulgaris, M Xanthoudaki, T Mouemin, M Froudarakis, P Steiropoulos

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The open cardiovascular medicine journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Obstructive Sleep Apnea, Sleepiness, and Glycemic Control in Type 2 Diabetes.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2019
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

K ArchontogeorgisMSc Program in Sleep Medicine, Medical School, Democritus University of Thrace, Alexandroupolis, Greece.
N PapanasSecond Department of Internal Medicine, Democritus University of Thrace, Alexandroupolis, Greece.
E NenaLaboratory of Hygiene and Environmental Protection, Medical School, Democritus University of Thrace, Alexandroupolis, Greece.
A TzouvelekisDivision of Immunology, Biomedical Sciences Research Center "Alexander Fleming", Athens, Greece.
C TsigalouLaboratory of Biopathology, University General Hospital of Evros, Alexandroupolis, Greece.
A VoulgarisDepartment of Pneumonology, Medical School, Democritus University of Thrace, Alexandroupolis , Greece.
M XanthoudakiDepartment of Pneumonology, Medical School, Democritus University of Thrace, Alexandroupolis , Greece.
T MoueminDepartment of Pneumonology, Medical School, Democritus University of Thrace, Alexandroupolis , Greece.
M FroudarakisDepartment of Pneumonology, Medical School, Democritus University of Thrace, Alexandroupolis , Greece.
P SteiropoulosMSc Program in Sleep Medicine, Medical School, Democritus University of Thrace, Alexandroupolis, Greece.
Democritus University of Thrace · GRAlexander Fleming Biomedical Sciences Research Center · GRUniversity Hospital of Alexandroupolis · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundObstructive sleep apnoea syndrome

methodsNon-diabetic patients (n=69) with OSAS, diagnosed by polysomnography, were prospectively recruited. To evaluate IR among OSAS patients, the Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) and Insulin sensitivity by Quantitative Insulin sensitivity Check Index (QUICKI) were used.

resultsHOMA-IR was positively associated with body-mass index (BMI) (ρ=0.364, p=0.002), time with oxyhaemoglobin saturation <90% (ρ=0.291, p=0.015), arousal index (ρ=0.268, p=0.027), Epworth sleepiness scale (ESS) score (ρ=0.293, p=0.019) and negatively with average oxyhaemoglobin saturation (ρ=-0.398, p=0.001) and minimum oxyhaemoglobin saturation (ρ=-0.327, p=0.006). QUICKI was positively associated with forced vital capacity (r=0.301, p=0.014), average oxyhaemoglobin saturation (r=0.443, p<0.001), minimum oxyhaemoglobin saturation (ρ=0.318, p=0.008), and negatively associated with sleep stage transitions (r=-0.266, p=0.032), oxygen desaturation index (r=-0.404, p=0.005), time with oxyhaemoglobin saturation <90% (r=-0.311, p=0.019), arousal index (r=-0.344, p=0.004) and ESS score (r=-0.299, p=0.016). After adjustment for age and BMI, HOMA-IR was associated with sleep stage transitions, time with oxyhaemoglobin saturation <90%, average oxyhaemoglobin saturation, minimum oxyhaemoglobin saturation and arousal index. QUICKI was associated with oxygen desaturation index, sleep stage transitions, ESS score, minimum oxyhaemoglobin saturation and arousal index.

conclusionsAn independent association between OSAS and IR in patients without pre-existing diabetes mellitus was observed. Recurrent hypoxia and sleep fragmentation in OSAS are associated with IR in these patients.

Indexed as

HOMA-IRInsulin resistanceInsulin sensitivityIntermittent hypoxiaObstructive sleep apnoea syndromeQUICKISleep fragmentation

Identifiers

PMID29399212
PMCPMC5761020
OpenAlexW2782123252

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.