ArticleBuilding and environment2017
Lessons from in-home air filtration intervention trials to reduce urban ultrafine particle number concentrations.
Article in Building and environment, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 34 citations in OpenAlex.
- Indoor particulate matter concentrations and air cleaner intervention association with biomarkers in former smokers with COPD.Environmental research · 2024Trial
- Effect of Reducing Ambient Traffic-Related Air Pollution on Blood Pressure: A Randomized Crossover Trial.Hypertension (Dallas, Tex. : 1979) · 2021Trial
- HEPA filtration improves asthma control in children exposed to traffic-related airborne particles.Indoor air · 2020Trial
- Pro-inflammatory cytokines moderated by visceral adiposity from a pragmatic randomized crossover trial of portable HEPA air purifiers.American journal of preventive cardiology · 2027Article
- Health Benefits of Air Purification: A Systematic Review.Environment & health (Washington, D.C.) · 2026Review
- Portable Air Cleaner Usage and Particulate Matter Exposure Reduction in an Environmental Justice Community: A Pilot Study.Environmental health insights · 2024Article
- Article
- Portable air cleaner use and biomarkers of inflammation: A systematic review and meta-analysis.American heart journal plus : cardiology research and practice · 2022Article
- A randomized crossover trial of HEPA air filtration to reduce cardiovascular risk for near highway residents: Methods and approach.Contemporary clinical trials · 2021Article
- Systemic inequalities in indoor air pollution exposure in London, UK.Buildings & cities · 2021Article
- Cardiopulmonary Impact of Particulate Air Pollution in High-Risk Populations: JACC State-of-the-Art Review.Journal of the American College of Cardiology · 2020Review
- Two communities, one highway and the fight for clean air: the role of political history in shaping community engagement and environmental health research translation.BMC public health · 2020Article
- Biomarkers and indoor air quality: A translational research review.Journal of clinical and translational science · 2020Article
- On the Need for Better Exposure Assessment for Air Pollution with High Spatial and Temporal Variation.International journal of environmental research and public health · 2019Article
- Combining Measurements from Mobile Monitoring and a Reference Site To Develop Models of Ambient Ultrafine Particle Number Concentration at Residences.Environmental science & technology · 2018Article
- Aviation-Related Impacts on Ultrafine Particle Number Concentrations Outside and Inside Residences near an Airport.Environmental science & technology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundExposure to airborne ultrafine particle (UFP; <100 nm in aerodynamic diameter) is an emerging public health problem. Nevertheless, the benefit of using high efficiency particulate arrestance (HEPA) filtration to reduce UFP concentrations in homes is not yet clear.
methodsWe conducted a randomized crossover study of HEPA filtration without a washout period in 23 homes of low-income Puerto Ricans in Boston and Chelsea, MA (USA). Most participants were female, older adults who were overweight or obese. Particle number concentrations (PNC, a proxy for UFP) were measured indoors and outdoors at each home continuously for six weeks. Homes received both HEPA filtration and sham filtration for three weeks each in random order.
resultsMedian PNC under HEPA filtration was 50-85% lower compared to sham filtration in most homes, but we found no benefit in terms of reduced inflammation; associations between hsCRP, IL-6, or TNFRII in blood samples and indoor PNC were inverse and not statistically significant.
conclusionsLimitations to our study design likely contributed to our findings. Limitations included carry-over effects, a population that may have been relatively unresponsive to UFP, reduction in PNC even during sham filtration that limited differences between HEPA and sham filtration, window opening by participants, and lack of fine-grained (room-specific) participant time-activity information. Our approach was similar to other recent HEPA intervention studies of particulate matter exposure and cardiovascular risk, suggesting that there is a need for better study designs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.