Evidence map›Paper›PMID 29398751›Full record

ArticleIranian journal of medical sciences2018

Radioprotective Efficacy of Lutein in Ameliorating Electron Beam Radiation-induced Oxidative Injury in Swiss Albino Mice.

Vidya Vasudeva, Yogish Somayaji Tenkanidiyoor, Alex John Peter, Jayaram Shetty, Srikant Patil Lakshman, Ronald Fernandes, Krishna Ananthapura Patali

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in Iranian journal of medical sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.2field-weighted citation impact, top 58% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Natural Guardians: Natural Compounds as Radioprotectors in Cancer Therapy.International journal of molecular sciences · 2024
    Review
  5. Article
  6. Article
  7. Research Progress on Dietary Intervention in Radiation Protection.Dose-response : a publication of International Hormesis Society
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Vidya VasudevaCentral Research Laboratory(CRL), K S Hegde Medical Academy, Nitte University, Mangalore, Karnataka.
Yogish Somayaji TenkanidiyoorCentral Research Laboratory(CRL), K S Hegde Medical Academy, Nitte University, Mangalore, Karnataka.
Alex John PeterDepartment of Oncology, Nitte Leela Narayana Shetty Memorial Cancer Institute, Mangalore, Karnataka.
Jayaram ShettyDepartment of Oncology, Nitte Leela Narayana Shetty Memorial Cancer Institute, Mangalore, Karnataka.
Srikant Patil LakshmanDepartment of Physiology, K S Hegde Medical Academy, Nitte University, Mangalore, Karnataka.
Ronald FernandesDepartment of Biochemistry, Nitte Gulabi Shetty Memorial Institute of Pharmaceutical Sciences, Nitte University, Mangalore, Karnataka.
Krishna Ananthapura PataliDepartment of Physiology, K S Hegde Medical Academy, Nitte University, Mangalore, Karnataka.
Nitte University · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLutein, a carotenoid compound, has previously been studied for its antioxidant and medicinal properties as well as the moderate protection it confers against gamma radiation. This study aimed at evaluating the effects of lutein against radiation-induced hematological and biochemical changes in mice.

methodsThe optimized dose of the compound was orally administered for 15 days, and the mice were irradiated (6 Gy) on day 15 after the administration of the compound. The groups were divided (6 mice in each group) into normal control, radiation control, gallic acid control, 10% DMSO control, lutein control, and irradiated groups pretreated with gallic acid, 10% DMSO, and lutein. Gallic acid was used to maintain a standard since it is a proven radioprotector. Within 24 hours post irradiation, the animals were anesthetized and sacrificed. The hematological, biochemical, and antioxidant changes were determined using suitable methods. Data were analyzed by the Kaplan-Meier curve (log-rank test) and ANOVA (the Tukey test). The independent

resultsMaximum survival was observed with a dose of 250 mg/kg b.wt lutein. The total leukocyte count and the percentage lymphocyte count exhibited a significant decline in the irradiated groups pretreated with gallic acid and lutein in comparison to their controls, whereas the percentage granulocyte count showed a significant rise. Antioxidant activity had markedly declined in the irradiated groups, indicating oxidative stress. Lutein pretreatment reduced the damage and maintained the antioxidant system.

conclusionThe present study suggests a protective role for lutein in palliating radiation-induced oxidative changes and maintaining the antioxidant system in vivo.

Indexed as

AntioxidantsCarotenoidsLuteinOxidative stress

Identifiers

PMID29398751
PMCPMC5775993
OpenAlexW2614810876

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.