Evidence map›Paper›PMID 29398653›Full record

ArticleEnvironmental health perspectives2018

Associations between Methylated Metabolites of Arsenic and Selenium in Urine of Pregnant Bangladeshi Women and Interactions between the Main Genes Involved.

Helena Skröder, Karin Engström, Doris Kuehnelt, Maria Kippler, Kevin Francesconi, Barbro Nermell, Fahmida Tofail, Karin Broberg, Marie Vahter

Open access · diamondAbstract read
In one paragraph

Article in Environmental health perspectives, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Helena SkröderInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Karin EngströmInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Doris KuehneltInstitute of Chemistry, NAWI Graz, University of Graz, Graz, Austria.
Maria KipplerInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Kevin FrancesconiInstitute of Chemistry, NAWI Graz, University of Graz, Graz, Austria.
Barbro NermellInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Fahmida TofailInternational Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.
Karin BrobergInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Marie VahterInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Karolinska Institutet · SEUniversity of Graz · ATInternational Centre for Diarrhoeal Disease Research · BDLund University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIt has been proposed that interactions between selenium and arsenic in the body may affect their kinetics and toxicity. However, it is unknown how the elements influence each other in humans.

objectivesWe aimed to investigate potential interactions in the methylation of selenium and arsenic.

methodsUrinary selenium (U-Se) and arsenic (U-As) were measured using inductively coupled plasma mass spectrometry (ICPMS) in samples collected from pregnant women (

resultsMultivariable-adjusted linear regression analyses indicated that %TMSe (at GW8) was positively associated with %MMA (β=1.3, 95% CI: 0.56, 2.0) and U-As, and inversely associated with %DMA and U-Se in producers of TMSe (

conclusionsOur findings for Bangladeshi women suggest a positive association between urinary %MMA and %TMSe. Genes involved in the methylation of selenium and arsenic may interact on associations with urinary %MMA. https://doi.org/10.1289/EHP1912.

Indexed as

AdolescentAdultArsenicArsenicalsBangladeshCacodylic AcidChromatography, High Pressure LiquidFemaleGenotypeHaplotypesHumansMass SpectrometryMethylationMethyltransferasesPregnancySeleniumArsenicArsenicalsAS3MT protein, humanCacodylic AcidMethyltransferasesmonomethylarsonic acidSeleniumtryptamine N-methyltransferase

Identifiers

PMID29398653
PMCPMC6066347
OpenAlexW2791354224

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.