ArticleCell host & microbe2018
Bacteroides fragilis Toxin Coordinates a Pro-carcinogenic Inflammatory Cascade via Targeting of Colonic Epithelial Cells.
Erratum issuedOpen access · bronzeAbstract read
In one paragraph
Article in Cell host & microbe, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 368 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
368citing papers in PubMed, 2 pooled it
28.9field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
368 citing papers in PubMed, 2 syntheses or guidelines pooled it, 601 citations in OpenAlex.
- The current status and prospects of gut microbiota combined with PD-1/PD-L1 inhibitors in the treatment of colorectal cancer: a review.BMC gastroenterology · 2025Pooled it
- Intestinal microbiota and biliary system diseases.Frontiers in cellular and infection microbiology · 2024Pooled it
- The protease code of the bacterial gut microbiota: ecological regulation, barrier disruption, and rewiring host defense and signaling.Gut microbes · 2026Review
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- Recent advances and clinical relevance of microbiome dynamics in health and disease.Gut microbes · 2026Review
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- Gastrointestinal Microbiome Dysbiosis in Cancer Development: Mechanisms and Biomarker Potential.MicrobiologyOpen · 2026Review
- Intratumoral microbiota in the growth of CRC and lung cancer: Comprehensive insights from etiology to therapy.iScience · 2026Review
- Bacteroides fragilis toxin promotes gall bladder cancer in mice.Nature microbiology · 2026Article
- Microbial Signals in Cancer: Dissecting Host-Microbiota-Tumor Interactions and Potential Therapeutic Strategy.MedComm · 2026Review
- Live Biotherapeutic Products (LBPs) as Promising Microbiome-Based Medicines for Colorectal Cancer (CRC): Mechanistic Basis, Therapeutic Applications, and Translational Challenges.Probiotics and antimicrobial proteins · 2026Review
- Targeting GLP-1R and IL-17A suppresses obesity-induced leukemia in an oncogenic PTPN11 mutation-driven model.The Journal of clinical investigation · 2026Article
- eIF6 deficiency alleviates colorectal cancer by modulating the gut microbiota and related metabolites.Cell death and differentiation · 2026Article
- Innovative technologies and future perspectives in tumor microbiomics.Science China. Life sciences · 2026Review
- Differential Expression and Co-Variation of HERV-Associated Transcripts, IL-17 Cytokines, and NFκB in Paired Colorectal Cancer Tissues.Biomedicines · 2026Article
- Microbiome-Shaped Metastatic Niches in Colorectal Cancer: Organ-Specific Patterns, Immune-Metabolic Mechanisms, and Therapeutic Translation.Microorganisms · 2026Review
- Gut microbiota in health and disease.Molecular biomedicine · 2026Review
- Outer membrane vesicles secreted byInfection and immunity · 2026Article
- Review
308 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Commented on by
- Erratum issued
Authors and funding
25 authors at 3 institutions in 2 countries.
Liam ChungBloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, MD 21287, USA; Translational Tissue Engineering Center, Wilmer Eye Institute and Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21287, USA.
Erik Thiele OrbergDepartment of Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, MD 21287, USA.
Abby L GeisDepartment of Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, MD 21287, USA.
June L ChanDepartment of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA.
Kai FuDepartment of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA.
Christina E DeStefano ShieldsDepartment of Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, MD 21287, USA.
Christine M DejeaDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Payam FathiDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Jie ChenDepartment of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA.
Benjamin B FinardBloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, MD 21287, USA.
Ada J TamBloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, MD 21287, USA.
Florencia McAllisterDepartment of Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, MD 21287, USA.
Hongni FanBloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, MD 21287, USA.
Xinqun WuDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Sudipto GangulyBloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, MD 21287, USA.
Andriana LebidBloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, MD 21287, USA.
Paul MetzDepartment of Pathology, Radboud University Medical Centre, Geert Grooteplein-Zuid 10, 6525 GA, Nijmegen, Netherlands.
Sara W Van MeerbekeDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
David L HusoDepartment of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Elizabeth C WickDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Drew M PardollBloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, MD 21287, USA.
Fengyi WanDepartment of Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, MD 21287, USA; Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA; Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA.
Shaoguang WuDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Cynthia L SearsBloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, MD 21287, USA; Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. Electronic address: csears@jhmi.edu.
Franck HousseauBloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, MD 21287, USA. Electronic address: fhousse1@jhmi.edu.
Johns Hopkins University · USBloomberg (United States) · USRadboud University Nijmegen · NL
Funding
Translational Research Central ServicesP30CA006973 · NCI · JOHNS HOPKINS UNIVERSITY · PI Rosalie Wollett · 1985 to 2026
$208.6MTumor Antigens for Individual Signatures and TherapyP50CA062924 · NCI · JOHNS HOPKINS UNIVERSITY · PI LENNON, ANNE MARIE · 1993 to 2022
$54.6MTranslational Research Enhancement CoreP30DK089502 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI ZACHOS, NICHOLAS CONSTANTINE · 2011 to 2020
$12.0MPARylation in genotoxic stress-induced NF-kB activation Supplement for Research on Sex/Gender InfluencesR01GM111682 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI WAN, FENGYI · 2015 to 2019
$2.0MMechanisms of Interleukin-17 Inflammation Induced by Bacteroides fragilisR01DK080817 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI SEARS, CYNTHIA · 2008 to 2012
$1.7MMechanisms of TH17 Inflammation-Induced Colon CarcihogenesisR01CA151325 · NCI · JOHNS HOPKINS UNIVERSITY · PI PARDOLL, DREW M., SEARS, CYNTHIA · 2010 to 2014
$1.6MRole of Stat3 in Colonic InflammationK08DK087856 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI WICK, ELIZABETH C · 2010 to 2014
$788kSite-specific DNA recombinase and A/E pathogen virulenceR21AI137719 · NIAID · JOHNS HOPKINS UNIVERSITY · PI WAN, FENGYI · 2019 to 2020
$450kNCI NIH HHS P30 CA006973NCI NIH HHS P50 CA062924NCI NIH HHS R01 CA151325NIAID NIH HHS R21 AI137719NIDDK NIH HHS K08 DK087856NIDDK NIH HHS P30 DK089502NIDDK NIH HHS R01 DK080817NIGMS NIH HHS R01 GM111682
Abstract
Pro-carcinogenic bacteria have the potential to initiate and/or promote colon cancer, in part via immune mechanisms that are incompletely understood. Using Apc
Indexed as
Adenomatous Polyposis Coli ProteinAnimalsBacterial ToxinsBacteroides fragilisCarcinogenesisCell Line, TumorColonColorectal NeoplasmsEnzyme ActivationEpithelial CellsFemaleGene DeletionHT29 CellsHumansInflammationInterleukin-17Adenomatous Polyposis Coli ProteinBacterial ToxinsBacteroides fragilis toxinIl17a protein, mouseIl17ra protein, mouseInterleukin-17MetalloendopeptidasesReceptors, Interleukin-17Receptors, Interleukin-8BRela protein, mouseStat3 protein, mouseSTAT3 Transcription FactorTranscription Factor RelAcolorectal cancerinflammationmucosal immunologymyeloid cellsNf-κBSTAT-3
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.