Evidence map›Paper›PMID 29398595›Full record

ReviewEBioMedicine2018

Ischemia-Reperfusion Injury Reduces Long Term Renal Graft Survival: Mechanism and Beyond.

Hailin Zhao, Azeem Alam, Aurelie Pac Soo, Andrew J T George, Daqing Ma

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in EBioMedicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07726134 (A Pilot Randomized, Surgeon-blinded, Trial of Intraoperative Furosemide Versus Mannitol Among Deceased Donor Kidney Transplant Recipients), which is not on this map. Cited by 199 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
199citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07726134 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

A Pilot Randomized, Surgeon-blinded, Trial of Intraoperative Furosemide Versus Mannitol Among Deceased Donor Kidney Transplant Recipients

TypeinterventionalSponsorLondon Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph'sRan2026 to 2028Enrolled160ConditionsDelayed Graft Function, Kidney TransplantationArmsFurosemide, Mannitol
3 · Its place in the literature

Who cites it

199 citing papers in PubMed, 8 syntheses or guidelines pooled it.

  1. Pooled it
  2. Impact of Vascular Anastomosis Time on Kidney Transplant Outcomes - A Systematic Review.Transplant international : official journal of the European Society for Organ Transplantation · 2026
    Pooled it
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  7. Perfusate Composition and Duration ofTransplant international : official journal of the European Society for Organ Transplantation · 2022
    Pooled it
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139 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hailin ZhaoAnaesthetics, Pain Medicine and Intensive Care, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Chelsea & Westminster Hospital, London, UK.
Azeem AlamAnaesthetics, Pain Medicine and Intensive Care, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Chelsea & Westminster Hospital, London, UK.
Aurelie Pac SooAnaesthetics, Pain Medicine and Intensive Care, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Chelsea & Westminster Hospital, London, UK.
Andrew J T GeorgeBrunel University London, Uxbridge, Middlesex, UK.
Daqing MaAnaesthetics, Pain Medicine and Intensive Care, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Chelsea & Westminster Hospital, London, UK. Electronic address: d.ma@imperial.ac.uk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ischemia-reperfusion injury (IRI) during renal transplantation often initiates non-specific inflammatory responses that can result in the loss of kidney graft viability. However, the long-term consequence of IRI on renal grafts survival is uncertain. Here we review clinical evidence and laboratory studies, and elucidate the association between early IRI and later graft loss. Our critical analysis of previous publications indicates that early IRI does contribute to later graft loss through reduction of renal functional mass, graft vascular injury, and chronic hypoxia, as well as subsequent fibrosis. IRI is also known to induce kidney allograft dysfunction and acute rejection, reducing graft survival. Therefore, attempts have been made to substitute traditional preserving solutions with novel agents, yielding promising results.

Indexed as

Graft SurvivalKidney TransplantationAnimalsHumansModels, BiologicalReperfusion InjuryAcute rejectionGraft survivalIschemia-reperfusionRenal transplantationTh cells: T helper cells

Identifiers

PMID29398595
PMCPMC5835570

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.