Evidence map›Paper›PMID 29398575›Full record

ReviewBrain stimulation

Rigor and reproducibility in research with transcranial electrical stimulation: An NIMH-sponsored workshop.

Marom Bikson, Andre R Brunoni, Leigh E Charvet, Vincent P Clark, Leonardo G Cohen, Zhi-De Deng, Jacek Dmochowski, Dylan J Edwards, Flavio Frohlich, Emily S Kappenman and 14 more

Registry-linked trialOpen access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Brain stimulation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06048159 (TACS for the Recovery of Phonological STM After Stroke), which is not on this map. Cited by 102 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
102citing papers in PubMed, 12 pooled it
12.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06048159 narecruitingnot on this map

TACS for the Recovery of Phonological STM After Stroke

TypeinterventionalSponsorMedical College of WisconsinRan2023 to 2033Enrolled120ConditionsStroke, AphasiaArmsHD-tACS, Sham HD-tACS
3 · Its place in the literature

Who cites it

102 citing papers in PubMed, 12 syntheses or guidelines pooled it, 209 citations in OpenAlex.

  1. Pooled it
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  6. Digitalized transcranial electrical stimulation: A consensus statement.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2022
    Pooled it
  7. Evidence-based umbrella review of cognitive effects of prefrontal tDCS.Social cognitive and affective neuroscience · 2022
    Pooled it
  8. Safety and recommendations for TMS use in healthy subjects and patient populations, with updates on training, ethical and regulatory issues: Expert Guidelines.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2021
    Guideline
  9. Pooled it
  10. A Systematic Review of Noninvasive Brain Stimulation for Opioid Use Disorder.Neuromodulation : journal of the International Neuromodulation Society · 2020
    Pooled it
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  19. Distinct trajectories of response to prefrontal tDCS in major depression: results from a 3-arm randomized controlled trial.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021
    Trial
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42 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 14 institutions in 3 countries.

Marom BiksonDepartment of Biomedical Engineering, The City College of the City University of New York, United States.
Andre R BrunoniLaboratory of Neurosciences (LIM-27), Department and Institute of Psychiatry, University of Sao Paulo, Sao Paulo, Brazil.
Leigh E CharvetDepartment of Neurology, New York University School of Medicine, New York, NY, United States.
Vincent P ClarkDepartment of Psychology, University of New Mexico, Albuquerque, NM, United States.
Leonardo G CohenHuman Cortical Physiology and Neurorehabilitation Section, National Institute of Neurological Disorders and Stroke, Bethesda, MD, United States.
Zhi-De DengExperimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, Bethesda, MD, United States.
Jacek DmochowskiDepartment of Biomedical Engineering, The City College of the City University of New York, United States.
Dylan J EdwardsNon-invasive Brain Stimulation and Human Motor Control Laboratory, Burke Rehabilitation and Research, Burke-Cornell Medical Research Facility, White Plains, New York and School of Medicine and Health Sciences, Edith Cowan University, Perth, Australia.
Flavio FrohlichDepartment of Psychiatry, Cell Biology and Physiology, Biomedical Engineering, and Neurology, Carolina Center for Neurostimulation, University of North Carolina School of Medicine, Chapel Hill, NC, United States.
Emily S KappenmanDepartment of Psychology, San Diego State University, San Diego, CA, United States.
Kelvin O LimDepartment of Psychiatry, University of Minnesota, Minneapolis Veterans Administration Health Care System, and Defense Veterans Brain Injury Center, Minneapolis, MN, United States.
Colleen LooSchool of Psychiatry and Black Dog Institute, University of New South Wales, Sydney, Australia.
Antonio MantovaniDepartment of Physiology, Pharmacology and Neuroscience, City College of the City University of New York, New York, NY, United States.
David P McMullenDivision of Translational Research, National Institute of Mental Health, Bethesda, MD, United States.
Lucas C ParraDepartment of Biomedical Engineering, The City College of the City University of New York, United States.
Michele PearsonDivision of Translational Research, National Institute of Mental Health, Bethesda, MD, United States.
Jessica D RichardsonDepartment of Speech and Hearing Sciences, University of New Mexico, Albuquerque, NM, United States.
Judith M RumseyDivision of Translational Research, National Institute of Mental Health, Bethesda, MD, United States. Electronic address: jrumsey@mail.nih.gov.
Pejman SehatpourDepartment of Psychiatry, Columbia University, New York, NY, United States.
David SommersScientific Review Branch, National Institute of Mental Health, Bethesda, MD, United States.
Gozde UnalDepartment of Biomedical Engineering, The City College of the City University of New York, United States.
Eric M WassermannBehavioral Neurology Unit, National Institute of Neurological Disorders and Stroke, Bethesda, MD, United States.
Adam J WoodsDepartment of Clinical and Health Psychology, Center for Cognitive Aging and Memory, McKnight Brain Institute, University of Florida, Gainesville, FL, United States.
Sarah H LisanbyDivision of Translational Research, National Institute of Mental Health, Bethesda, MD, United States.
National Institute of Mental Health · USCity College of New York · USNational Institute of Neurological Disorders and Stroke · USUniversity of New Mexico · USBlack Dog Institute · AUCity University of New York · USColumbia University · USCornell University · USMinneapolis VA Health Care System · USNew York University · USSan Diego State University · USUniversidade de São Paulo · BRUniversity of Florida · USUniversity of North Carolina at Chapel Hill · US

Funding

Non-invasive Neuromodulation Unit (NNU)ZIAMH002955 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI ZARATE, CARLOS · 2016 to 2025
$40.3M
Training and Career Development CoreU54CA132378 · NCI · CITY COLLEGE OF NEW YORK · PI Tim Alan Ahles, ADRIANA ESPINOSA · 2008 to 2026
$28.9M
Training and Career Development and Education CoreU54CA137788 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI ADRIANA ESPINOSA, FRANCESCA M GANY · 2008 to 2026
$28.1M
University of New Mexico (UNM) Center for Brain Recovery and RepairP20GM109089 · NIGMS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI BOYCE, ANDREW · 2015 to 2024
$22.7M
Electrophysiological Probes And Treatments In Neurobehavioral DisordersZIANS002977 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI WASSERMANN, ERIC M · 2009 to 2025
$14.6M
Augmenting Cognitive Training in Older Adults - The ACT GrantR01AG054077 · NIA · UNIVERSITY OF FLORIDA · PI COHEN, RONALD A, MARSISKE, MICHAEL · 2016 to 2020
$6.9M
Transcranial Direct Current Stimulation and Robotic Training in Chronic StrokeR01HD069776 · NICHD · WINIFRED MASTERSON BURKE MED RES INST · PI EDWARDS, DYLAN JAMES · 2012 to 2016
$3.2M
Neuromodulation of Cognition in Older AdultsK01AG050707 · NIA · UNIVERSITY OF FLORIDA · PI WOODS, ADAM J. · 2016 to 2020
$613k
NCI NIH HHS U54 CA132378NCI NIH HHS U54 CA137788NIA NIH HHS K01 AG050707NIA NIH HHS R01 AG054077NICHD NIH HHS R01 HD069776NIGMS NIH HHS P20 GM109089
6 · The paper itself

Abstract

backgroundNeuropsychiatric disorders are a leading source of disability and require novel treatments that target mechanisms of disease. As such disorders are thought to result from aberrant neuronal circuit activity, neuromodulation approaches are of increasing interest given their potential for manipulating circuits directly. Low intensity transcranial electrical stimulation (tES) with direct currents (transcranial direct current stimulation, tDCS) or alternating currents (transcranial alternating current stimulation, tACS) represent novel, safe, well-tolerated, and relatively inexpensive putative treatment modalities.

objectiveThis report seeks to promote the science, technology and effective clinical applications of these modalities, identify research challenges, and suggest approaches for addressing these needs in order to achieve rigorous, reproducible findings that can advance clinical treatment.

methodsThe National Institute of Mental Health (NIMH) convened a workshop in September 2016 that brought together experts in basic and human neuroscience, electrical stimulation biophysics and devices, and clinical trial methods to examine the physiological mechanisms underlying tDCS/tACS, technologies and technical strategies for optimizing stimulation protocols, and the state of the science with respect to therapeutic applications and trial designs.

resultsAdvances in understanding mechanisms, methodological and technological improvements (e.g., electronics, computational models to facilitate proper dosing), and improved clinical trial designs are poised to advance rigorous, reproducible therapeutic applications of these techniques. A number of challenges were identified and meeting participants made recommendations made to address them.

conclusionsThese recommendations align with requirements in NIMH funding opportunity announcements to, among other needs, define dosimetry, demonstrate dose/response relationships, implement rigorous blinded trial designs, employ computational modeling, and demonstrate target engagement when testing stimulation-based interventions for the treatment of mental disorders.

Indexed as

EducationHumansMental DisordersNational Institute of Mental Health (U.S.)Reproducibility of ResultsResearch DesignTranscranial Direct Current StimulationUnited StatesNeuromodulationReproducibilityTranscranial alternating current stimulation (tACS)Transcranial direct current stimulation (tDCS)Transcranial electrical stimulation (tES)

Identifiers

PMID29398575
PMCPMC5997279
OpenAlexW2778005188

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.