ArticleNeuroImage2019
Dual regression physiological modeling of resting-state EPI power spectra: Effects of healthy aging.
Article in NeuroImage, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 20 citations in OpenAlex.
- Age-Related Low Frequency Amplitude Differences in Resting-State Blood Oxygenation Level-Dependent Signal in the Cerebellum.Human brain mapping · 2026Article
- fMRIflows: A Consortium of Fully Automatic Univariate and Multivariate fMRI Processing Pipelines.Brain topography · 2023Article
- BOLD cardiorespiratory pulsatility in the brain: from noise to signal of interest.Frontiers in human neuroscience · 2023Review
- Measuring brain beats: Cardiac-aligned fast functional magnetic resonance imaging signals.Human brain mapping · 2023Article
- Multimodal fusion analysis of functional, cerebrovascular and structural neuroimaging in healthy aging subjects.Human brain mapping · 2022Article
- Static and dynamic BOLD fMRI components along white matter fibre tracts and their dependence on the orientation of the local diffusion tensor axis relative to the BJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022Article
- Review
- Design of a randomised, double-blind, crossover, placebo-controlled trial of effects of sildenafil on cerebrovascular function in small vessel disease: Oxford haemodynamic adaptation to reduce pulsatility trial (OxHARP).European stroke journal · 2021Article
- The effects of age on resting-state BOLD signal variability is explained by cardiovascular and cerebrovascular factors.Psychophysiology · 2021Article
- Separating vascular and neuronal effects of age on fMRI BOLD signals.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Review
- Cortical laminar resting-state signal fluctuations scale with the hypercapnic blood oxygenation level-dependent response.Human brain mapping · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Aging and disease-related changes in the arteriovasculature have been linked to elevated levels of cardiac cycle-induced pulsatility in the cerebral microcirculation. Functional magnetic resonance imaging (fMRI), acquired fast enough to unalias the cardiac frequency contributions, can be used to study these physiological signals in the brain. Here, we propose an iterative dual regression analysis in the frequency domain to model single voxel power spectra of echo planar imaging (EPI) data using external recordings of the cardiac and respiratory cycles as input. We further show that a data-driven variant, without external physiological traces, produces comparable results. We use this framework to map and quantify cardiac and respiratory contributions in healthy aging. We found a significant increase in the spatial extent of cardiac modulated white matter voxels with age, whereas the overall strength of cardiac-related EPI power did not show an age effect.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.