Evidence map›Paper›PMID 29398367›Full record

ReviewVascular pharmacology2019

Linking diabetic vascular complications with LncRNAs.

Amy Leung, Vishnu Amaram, Rama Natarajan

Abstract readReview
In one paragraph

Review in Vascular pharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.

  1. Pooled it
  2. Metabolic memory: mechanisms and diseases.Signal transduction and targeted therapy · 2024
    Review
  3. Research progress onFrontiers in pharmacology · 2024
    Review
  4. Facile Synthesis of MXene-TiMolecules (Basel, Switzerland) · 2023
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Review
  12. Article
  13. Article
  14. Review
  15. Long noncoding RNAAutophagy · 2020
    Article
  16. Metabolism, Obesity, and Diabetes Mellitus.Arteriosclerosis, thrombosis, and vascular biology · 2019
    Article
  17. Epigenetics and Type 2 Diabetes Risk.Current diabetes reports · 2019
    Review
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Amy LeungDepartment of Diabetes Complications and Metabolism, Diabetes and Metabolic Research Institute, 1500 East Duarte Road, Duarte, CA 91010, United States.
Vishnu AmaramDepartment of Diabetes Complications and Metabolism, Diabetes and Metabolic Research Institute, 1500 East Duarte Road, Duarte, CA 91010, United States; Irell and Manella Graduate School of Biological Sciences, Beckman Research Institute of City of Hope, 1500 East Duarte Road, Duarte, CA 91010, United States.
Rama NatarajanDepartment of Diabetes Complications and Metabolism, Diabetes and Metabolic Research Institute, 1500 East Duarte Road, Duarte, CA 91010, United States; Irell and Manella Graduate School of Biological Sciences, Beckman Research Institute of City of Hope, 1500 East Duarte Road, Duarte, CA 91010, United States. Electronic address: RNatarajan@coh.org.
City of Hope · US

Funding

Inflammatory Gene Transcription In Diabetic ConditionsR01DK065073 · NIDDK · CITY OF HOPE/BECKMAN RESEARCH INSTITUTE · PI NATARAJAN, RAMA · 2003 to 2021
$7.9M
Transcriptional Regulation by Angiotensin II in Vascular Smooth Muscle CellsR01HL106089 · NHLBI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI NATARAJAN, RAMA · 2011 to 2024
$6.6M
Transforming growth factor beta1, microRNAs, lncRNA and diabetic nephropathyR01DK081705 · NIDDK · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI NATARAJAN, RAMA · 2009 to 2023
$6.1M
ROLE OF 12-LIPOXYGENASE IN DIABETIC NEPHROPATHYR01DK058191 · NIDDK · CITY OF HOPE/BECKMAN RESEARCH INSTITUTE · PI NATARAJAN, RAMA · 2001 to 2016
$5.3M
Epigenetic Markers of Complications and Metabolic Memory in the DCCT/EDIC cohort.DP3DK106917 · NIDDK · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI NATARAJAN, RAMA · 2015 to 2015
$2.2M
Role of LncRNAs in diabetic liversK01DK104993 · NIDDK · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI LEUNG, AMY Y · 2015 to 2017
$462k
NHLBI NIH HHS R01 HL106089NIDDK NIH HHS DP3 DK106917NIDDK NIH HHS K01 DK104993NIDDK NIH HHS R01 DK058191NIDDK NIH HHS R01 DK065073NIDDK NIH HHS R01 DK081705
6 · The paper itself

Abstract

Diabetes leads to markedly accelerated rates of many associated macrovascular complications like hypertension and atherosclerosis, and microvascular complications like nephropathy and retinopathy. High glucose, the hallmark of diabetes, drives changes in vascular and inflammatory cells that promote the development of these complications. Understanding the molecular processes involved in the development of diabetes and its debilitating complications can lead to much needed newer clinical therapies. Recently, long-noncoding RNAs (lncRNAs) have been shown to be important in the biology of vascular cells and there is growing evidence that lncRNAs are also involved in the cell biology relevant to diabetic vascular complications. In this review, we provide an overview of lncRNAs that function in vascular cells, and those that have been linked to diabetic complications.

Indexed as

AnimalsArteriesDiabetic AngiopathiesEndothelial CellsGene Expression RegulationHumansMacrophagesMuscle, Smooth, VascularMyocytes, Smooth MuscleRNA, Long NoncodingSignal TransductionRNA, Long NoncodingDiabetic vascular complicationsEndotheliallncRNAsMacrophageVascular smooth muscle cells

Identifiers

PMID29398367
PMCPMC6070440
OpenAlexW2793716160

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.