Evidence map›Paper›PMID 29398205›Full record

ArticleSchizophrenia research2018

Translocator protein (TSPO) and stress cascades in mouse models of psychosis with inflammatory disturbances.

Daisuke Fukudome, Lindsay N Hayes, Travis E Faust, Catherine A Foss, Mari A Kondo, Brian J Lee, Atsushi Saito, Shin-Ichi Kano, Jennifer M Coughlin, Atsushi Kamiya and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Schizophrenia research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Daisuke FukudomeDepartment of Psychiatry, Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Baltimore, MD 21287, USA.
Lindsay N HayesDepartment of Psychiatry, Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Baltimore, MD 21287, USA.
Travis E FaustDepartment of Psychiatry, Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Baltimore, MD 21287, USA.
Catherine A FossRussell H Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, 1550 Orleans Street, Baltimore, MD 21231, USA.
Mari A KondoDepartment of Psychiatry, Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Baltimore, MD 21287, USA.
Brian J LeeDepartment of Psychiatry, Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Baltimore, MD 21287, USA.
Atsushi SaitoDepartment of Psychiatry, Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Baltimore, MD 21287, USA.
Shin-Ichi KanoDepartment of Psychiatry, Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Baltimore, MD 21287, USA.
Jennifer M CoughlinDepartment of Psychiatry, Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Baltimore, MD 21287, USA.
Atsushi KamiyaDepartment of Psychiatry, Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Baltimore, MD 21287, USA.
Martin G PomperRussell H Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, 1550 Orleans Street, Baltimore, MD 21231, USA.
Akira SawaDepartment of Psychiatry, Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Baltimore, MD 21287, USA. Electronic address: asawa1@jhmi.edu.
Minae NiwaDepartment of Psychiatry, Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Baltimore, MD 21287, USA. Electronic address: mniwa1@jhmi.edu.
Johns Hopkins University · USJohns Hopkins Medicine · US

Funding

Project 3P50MH094268 · NIMH · JOHNS HOPKINS UNIVERSITY · PI LEEK, JEFFREY T. · 2011 to 2020
$19.9M
Training Program in Cellular and Molecular MedicineT32GM008752 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI RAO, RAJINI · 2000 to 2019
$11.7M
DISC1-dependent defects in neural fate, corticogenesis and cognition in psychosisR01MH105660 · NIMH · JOHNS HOPKINS UNIVERSITY · PI ISHIZUKA, KOKO, SAWA, AKIRA · 2014 to 2018
$2.8M
Oxidative stress and schizophrenia: combination of cell biology and brain imagingR01MH092443 · NIMH · JOHNS HOPKINS UNIVERSITY · PI SAWA, AKIRA · 2011 to 2015
$1.8M
DISC1 Pathway in Dendritogenesis: Implications for Dopamine Circuit and CognitionR01MH091230 · NIMH · JOHNS HOPKINS UNIVERSITY · PI KAMIYA, ATSUSHI · 2010 to 2014
$1.6M
Role of glia and inflammation in altered synapse development in schizophreniaR00MH093458 · NIMH · JOHNS HOPKINS UNIVERSITY · PI KANO, SHINICHI · 2014 to 2016
$737k
Preclinical model for co-morbid conditions that are relevant to addiction and depressionR21DA040127 · NIDA · JOHNS HOPKINS UNIVERSITY · PI NIWA, MINAE, SAWA, AKIRA · 2015 to 2016
$443k
Exploring depressive behavior using a natural product for novel drug targetsR21AT008547 · NCCIH · JOHNS HOPKINS UNIVERSITY · PI KAMIYA, ATSUSHI · 2014 to 2015
$439k
Roles of Stress and Glucocorticoids in Dopaminergic Projections and BehaviorsK99MH094408 · NIMH · JOHNS HOPKINS UNIVERSITY · PI NIWA, MINAE · 2012 to 2013
$149k
NCCIH NIH HHS R21 AT008547NIDA NIH HHS R21 DA040127NIGMS NIH HHS T32 GM008752NIMH NIH HHS K99 MH094408NIMH NIH HHS P50 MH094268NIMH NIH HHS R00 MH093458NIMH NIH HHS R01 MH091230NIMH NIH HHS R01 MH092443NIMH NIH HHS R01 MH105660
6 · The paper itself

Abstract

Changes in inflammatory cascades have been implicated in the underlying pathophysiology of psychosis. Translocator protein 18 kDa (TSPO) has been used to assess neuroinflammatory processes in psychotic disorders. Nonetheless, it is unclear whether TSPO, a mitochondrial protein, can be interpreted as a general marker for inflammation in diseases involving psychosis. To address this question, we investigated TSPO signaling in representative mouse models for psychosis with inflammatory disturbances. The maternal immune activation and cuprizone short-term exposure models show different TSPO signaling. Furthermore, we observed similarities and differences in their respective stress pathways including stress hormone signaling and oxidative stress that are functionally interconnected with the inflammatory responses. We propose that more careful studies of TSPO distribution in neuroinflammation and other stress cascades associated with psychotic symptoms will allow us to understand the biological mechanisms underlying psychosis-related behaviors.

Indexed as

Oxidative StressAnimalsCorticosteroneDisease Models, AnimalFemaleInflammationMaleMiceMice, Inbred C57BLPrefrontal CortexPregnancyPsychotic DisordersReceptors, GABAStress, PsychologicalBzrp protein, mouseCorticosteroneReceptors, GABACuprizone short-term exposure (CSE)Inflammatory disturbancesMaternal immune activation (MIA)PsychosisStress cascadesTranslocator protein 18 kDa (TSPO)

Identifiers

PMID29398205
PMCPMC6470041
OpenAlexW2790263596

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.