ArticleRadiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology2018
Prognostic significance of pretreatment total lymphocyte count and neutrophil-to-lymphocyte ratio in extensive-stage small-cell lung cancer.
Article in Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 4 of them syntheses that pooled it.
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46 citing papers in PubMed, 4 syntheses or guidelines pooled it, 63 citations in OpenAlex.
- The prognostic impact of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio on patients with small cell lung cancer receiving first-line platinum-based chemotherapy: a systematic review and meta-analysis.BMC pulmonary medicine · 2024Pooled it
- Platelet-lymphocyte ratio is a prognostic marker in small cell lung cancer-A systemic review and meta-analysis.Frontiers in oncology · 2022Pooled it
- Inflammation scores as prognostic biomarkers in small cell lung cancer: a systematic review and meta-analysis.Systematic reviews · 2021Pooled it
- Pooled it
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- Real-world evidence on the efficacy, safety, and biomarkers of immunotherapy combined with radiotherapy in limited-stage small cell lung cancer.Journal of thoracic disease · 2026Article
- The role of neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR) in the early diagnosis of pulmonary mucoepidermoid carcinoma and their clinical significance.Journal of medical biochemistry · 2026Article
- Evaluation of prognostic factors using nutritional indicators in extensive-stage small cell lung cancer.Journal of rural medicine : JRM · 2026Article
- Development and validation of a serum inflammatory biomarker-driven machine-learning model for prognostic stratification in surgical limited-stage small cell lung cancer.Translational lung cancer research · 2025Article
- First-line serplulimab-based immunochemotherapy in elderly patients with extensive-stage small cell lung cancer: a multicenter, real-world study.Journal of thoracic disease · 2025Article
- Prognostic value of pretreatment procalcitonin and neutrophil-lymphocyte ratio in extensive-stage small-cell lung cancer.Cancer biology & therapy · 2024Article
- Using MRI radiomics to predict the efficacy of immunotherapy for brain metastasis in patients with small cell lung cancer.Thoracic cancer · 2024Article
- Prognostic implications of neutrophil-to-lymphocyte ratio in patients with extensive-stage small cell lung cancer receiving chemoimmunotherapy: A multicenter, real-world study.Thoracic cancer · 2024Article
- Local control of bone metastasis treated with palliative radiotherapy in patients with lung cancer: An observational retrospective cohort study.Oncology letters · 2023Article
- Higher aorta dose increased neutrophil-to-lymphocyte ratio resulting in poorer outcomes in stage II-III non-small cell lung cancer.Thoracic cancer · 2023Article
- Prognostic significance of HALP score and combination of peripheral blood multiple indicators in patients with early breast cancer.Frontiers in oncology · 2023Article
- Nomogram combining clinical and radiological characteristics for predicting the malignant probability of solitary pulmonary nodules measuring ≤ 2 cm.Frontiers in oncology · 2023Article
- Effect of Lymphopenia on Tumor Response and Clinical Outcomes Following Chemoradiotherapy in Stage III Non-Small Cell Lung Cancer.Lung Cancer (Auckland, N.Z.) · 2023Article
- The prognostic value of the Naples prognostic score for patients with non-small-cell lung cancer.Scientific reports · 2022Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
backgroundWe evaluated pretreatment total lymphocyte count (TLC, marker of immunosuppression), neutrophil-to-lymphocyte ratio (NLR, marker of inflammation), and overall survival (OS) in patients with extensive-stage small-cell lung cancer (ES-SCLC).
methodsPretreatment blood characteristics, age, sex, performance status, race, stage (M1a vs. M1b), number and location of metastases, weight loss, smoking status, chemotherapy cycles (<4 vs. ≥4), thoracic radiotherapy dose (<45 vs. ≥45 Gy), and receipt of prophylactic cranial irradiation (PCI) were evaluated in 252 patients with ES-SCLC treated in 1998-2015. Factors significant in univariate analysis were selected as covariates for a multivariate Cox model.
resultsPretreatment TLC was below normal (<1.0 × 10
conclusionsPretreatment TLC and NLR may be useful for stratifying patients with ES-SCLC for treatment approaches.
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