Evidence map›Paper›PMID 29398129›Full record

ArticleInternational journal of radiation oncology, biology, physics2018

Biophysical Modeling of In Vivo Glioma Response After Whole-Brain Radiation Therapy in a Murine Model of Brain Cancer.

David A Hormuth, Jared A Weis, Stephanie L Barnes, Michael I Miga, Vito Quaranta, Thomas E Yankeelov

Abstract read
In one paragraph

Article in International journal of radiation oncology, biology, physics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Article
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  4. Identifiability and model selection frameworks for models of high-grade glioma response to chemoradiation.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2025
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  16. Towards integration ofScientific reports · 2020
    Article
  17. Article
  18. Translating preclinical MRI methods to clinical oncology.Journal of magnetic resonance imaging : JMRI · 2019
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

David A HormuthInstitute for Computational and Engineering Sciences, The University of Texas at Austin, Austin, Texas. Electronic address: david.hormuth@utexas.edu.
Jared A WeisDepartment of Biomedical Engineering, Wake Forest School of Medicine, Winston-Salem, North Carolina; Comprehensive Cancer Center, Wake Forest Baptist Medical Center, Winston-Salem, North Carolina.
Stephanie L BarnesInstitute for Computational and Engineering Sciences, The University of Texas at Austin, Austin, Texas.
Michael I MigaDepartment of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee; Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, Tennessee; Department of Neurological Surgery, Vanderbilt University, Nashville, Tennessee.
Vito QuarantaDepartment of Cancer Biology, Vanderbilt University, Nashville, Tennessee.
Thomas E YankeelovInstitute for Computational and Engineering Sciences, The University of Texas at Austin, Austin, Texas; Department of Biomedical Engineering, The University of Texas at Austin, Austin, Texas; Department of Internal Medicine, The University of Texas at Austin, Austin, Texas.

Funding

Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MATTHEW J TYSKA · 1995 to 2026
$172.8M
Multimodal Registration of the Brain's Cortical SurfaceR01NS049251 · NINDS · VANDERBILT UNIVERSITY · PI GOLBY, ALEXANDRA J, MIGA, MICHAEL IAN · 2005 to 2018
$6.7M
Multidisciplinary Training in Basic and Translational Imaging of CancerR25CA092043 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MANNING, HENRY CHARLES · 2001 to 2015
$6.6M
Quantitative MRI for Predicting Response of Breast Cancer to Neoadjuvant TherapyU01CA142565 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI KARCZMAR, GREGORY S., NANDA, RITA · 2010 to 2019
$4.5M
Quantitative Multiscale Imaging to Optimize Cancer Treatment StrategiesR01CA186193 · NCI · VANDERBILT UNIVERSITY · PI QUARANTA, VITO, RERICHA, ERIN C · 2014 to 2019
$3.1M
Image Driven Multi-Scale Modeling to Predict Treatment Response in Breast CancerU01CA174706 · NCI · VANDERBILT UNIVERSITY · PI QUARANTA, VITO, YANKEELOV, THOMAS E · 2013 to 2018
$2.5M
Evaluation and Validation of Imaging Biomarkers of Tumor Response to TreatmentR01CA138599 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MCINTYRE, JAMES OLIVER · 2010 to 2015
$2.2M
Multi-Scale Biomechanical Modeling of Tumor Growth and Response in Breast CancerK25CA204599 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI WEIS, JARED ANTHONY · 2016 to 2020
$747k
Integrating Quantitative Imaging and Biophysical Models to Predict Tumor GrowthR21CA169387 · NCI · VANDERBILT UNIVERSITY · PI YANKEELOV, THOMAS E · 2013 to 2014
$368k
NCI NIH HHS K25 CA204599NCI NIH HHS P30 CA068485NCI NIH HHS R01 CA138599NCI NIH HHS R01 CA186193NCI NIH HHS R21 CA169387NCI NIH HHS R25 CA092043NCI NIH HHS U01 CA142565NCI NIH HHS U01 CA174706NINDS NIH HHS R01 NS049251
6 · The paper itself

Abstract

purposeTo develop and investigate a set of biophysical models based on a mechanically coupled reaction-diffusion model of the spatiotemporal evolution of tumor growth after radiation therapy. METHODS AND MATERIALS: Post-radiation therapy response is modeled using a cell death model (M

resultsFor both the rats treated with either 20 or 40 Gy, significantly lower error in tumor volume, average surface distance, and voxel-based cell number was observed for the M

conclusionsThe results of this study indicate that for both doses, the M

Indexed as

Cranial IrradiationModels, BiologicalAnimalsBrain NeoplasmsCell DeathCell ProliferationContrast MediaDiffusion Magnetic Resonance ImagingDisease Models, AnimalFemaleGliomaMagnetic Resonance ImagingRadiation DosageRatsRats, WistarTreatment OutcomeContrast Media

Identifiers

PMID29398129
PMCPMC5934308

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.