Evidence map›Paper›PMID 29398125›Full record

ArticleSeminars in arthritis and rheumatism2018

Health-related quality of life in gout in primary care: Baseline findings from a cohort study.

Priyanka Chandratre, Christian Mallen, Jane Richardson, Sara Muller, Samantha Hider, Keith Rome, Milisa Blagojevic-Bucknall, Edward Roddy

Erratum issued Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Seminars in arthritis and rheumatism, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT04587544 (Effect of a Cold Water Immersion), which is not on this map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04587544 nacompletednot on this mapstarted 2019, after this paper: background citation

Effect of a Cold Water Immersion (CWI) on Pain in People With Gouty Arthritis: A Community Based Randomized Controlled Trial

TypeinterventionalSponsorTaipei Medical UniversityRan2019 to 2021Enrolled76ConditionsGout ArthritisArmsCold Water Immersion
3 · Its place in the literature

Who cites it

29 citing papers in PubMed.

  1. Trial
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  4. Erectile Dysfunction and Oxidative Stress: A Narrative Review.International journal of molecular sciences · 2025
    Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Priyanka ChandratreResearch Institute for Primary Care and Health Sciences, Keele University, Keele, Staffordshire ST5 5BG, UK.
Christian MallenResearch Institute for Primary Care and Health Sciences, Keele University, Keele, Staffordshire ST5 5BG, UK.
Jane RichardsonResearch Institute for Primary Care and Health Sciences, Keele University, Keele, Staffordshire ST5 5BG, UK.
Sara MullerResearch Institute for Primary Care and Health Sciences, Keele University, Keele, Staffordshire ST5 5BG, UK.
Samantha HiderResearch Institute for Primary Care and Health Sciences, Keele University, Keele, Staffordshire ST5 5BG, UK; Haywood Academic Rheumatology Centre, Haywood Hospital, Stoke-on-Trent, UK.
Keith RomeAuckland University of Technology, Auckland, New Zealand.
Milisa Blagojevic-BucknallResearch Institute for Primary Care and Health Sciences, Keele University, Keele, Staffordshire ST5 5BG, UK.
Edward RoddyResearch Institute for Primary Care and Health Sciences, Keele University, Keele, Staffordshire ST5 5BG, UK; Haywood Academic Rheumatology Centre, Haywood Hospital, Stoke-on-Trent, UK. Electronic address: e.roddy@keele.ac.uk.

Funding

Department of Health RP_2014-04-026
6 · The paper itself

Abstract

objectivesTo examine gout-related, comorbid, and sociodemographic characteristics associated with generic and disease-specific health-related quality of life (HRQOL) in gout.

methodsAdults with gout from 20 general practices were mailed a questionnaire containing the Health Assessment Questionnaire-Disability Index (HAQ-DI), Short-Form-36 Physical Function subscale (PF-10), Gout Impact Scale (GIS), and questions about gout-specific, comorbid and sociodemographic characteristics. Variables associated with HRQOL were examined using multivariable linear regression models.

resultsA total of 1184 completed questionnaires were received (response 65.9%). Worse generic and gout-specific HRQOL was associated with frequent gout attacks (≥5 attacks PF-10 β = -4.90, HAQ-DI β = 0.14, GIS subscales β = 8.94, 33.26), current attack (HAQ-DI β = 0.15, GIS β = -1.94, 18.89), oligo/polyarticular attacks (HAQ-DI β = 0.11, GIS β = 0.78, 7.86), body pain (PF-10 β = -10.68, HAQ-DI β = 0.29, GIS β = 2.61, 11.89), anxiety (PF-10 β = -1.81, HAQ-DI β = 0.06, GIS β = 0.38, 1.70), depression (PF-10 β = -1.98, HAQ-DI β = 0.06, GIS 0.42, 1.47) and alcohol non-consumption (PF-10 β = -16.10, HAQ-DI β = 0.45). Gout-specific HRQOL was better in Caucasians than non-Caucasians (GIS β = -13.05, -13.48). Poorer generic HRQOL was associated with diabetes mellitus (PF-10 β = -4.33, HAQ-DI β = 0.14), stroke (PF-10 β = -12.21, HAQ-DI β = 0.37), renal failure (PF-10 β = -9.43, HAQ-DI β = 0.21), myocardial infarction (HAQ-DI β = 0.17), female gender (PF-10 β = -17.26, HAQ-DI β = 0.43), deprivation (PF-10 β = -7.80, HAQ-DI β = 0.19), and body mass index ≥35kg/m

conclusionsHRQOL in gout is impaired by gout-specific, comorbid, and sociodemographic characteristics, highlighting the importance of comorbidity screening and early urate-lowering therapy. Both gout-specific and generic questionnaires identify the impact of disease-specific features on HRQOL but studies focusing on comorbidity should include generic instruments.

Indexed as

Health StatusQuality of LifeAgedCohort StudiesCross-Sectional StudiesDisability EvaluationFemaleGoutHumansMaleMiddle AgedPrimary Health CareSeverity of Illness IndexSurveys and QuestionnairesComorbidityGoutHealth related quality of lifePrimary care

Identifiers

PMID29398125
PMCPMC6089841

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.