Evidence map›Paper›PMID 29398066›Full record

ReviewProgress in biophysics and molecular biology2018

Living tissues are more than cell clusters: The extracellular matrix as a driving force in morphogenesis.

Marta Linde-Medina, Ralph Marcucio

Abstract readReview
In one paragraph

Review in Progress in biophysics and molecular biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Downstream branches of receptor tyrosine kinase signaling act interdependently to shape the face.Developmental dynamics : an official publication of the American Association of Anatomists · 2025
    Article
  2. Review
  3. Tissue Engineering with Mechanically Induced Solid-Fluid Transitions.Advanced materials (Deerfield Beach, Fla.) · 2022
    Article
  4. Review
  5. Modern Approaches to Acellular Therapy in Bone and Dental Regeneration.International journal of molecular sciences · 2021
    Review
  6. Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Marta Linde-MedinaDepartment of Orthopaedic Surgery, San Francisco General Hospital, Orthopaedic Trauma Institute, University of California, San Francisco, CA 94110, USA. Electronic address: linde.m@outlook.com.
Ralph MarcucioDepartment of Orthopaedic Surgery, San Francisco General Hospital, Orthopaedic Trauma Institute, University of California, San Francisco, CA 94110, USA.

Funding

The role of continuous phenotypic variation in structural defects of the faceR01DE019638 · NIDCR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Benedikt Hallgrimsson, Ralph S Marcucio · 2010 to 2026
$7.3M
MOLECULAR BASIS OF TISSUE INTERACTIONS THAT REGULATE CRANIOFACIAL DEVELOPMENTR01DE018234 · NIDCR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MARCUCIO, RALPH S · 2007 to 2017
$3.5M
NIDCR NIH HHS R01 DE018234NIDCR NIH HHS R01 DE019638
6 · The paper itself

Abstract

In the study of morphogenesis, there is a general tendency to look at the extracellular matrix (ECM) as a mechanically passive agent that simply gives support to cells, and consequently, to place all the explanatory burden on cellular behaviors. Here we aimed to show that not only cells, but also the ECM may be an important force of morphogenesis. Understanding the mechanical role of the ECM broadens our view of morphogenesis and stresses the importance of considering embryonic tissues as a composite of cells and ECM.

Indexed as

MorphogenesisAnimalsExtracellular MatrixBuddingEvaginationInvaginationMechanical forcesMorphological motifs

Identifiers

PMID29398066
PMCPMC6068072

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.