ArticleFertility and sterility2018
Dehydroepiandrosterone enhances decidualization in women of advanced reproductive age.
Article in Fertility and sterility, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- Efficacy of dehydroepiandrosterone priming in women with poor ovarian response undergoing IVF/ICSI: a meta-analysis.Frontiers in endocrinology · 2023Pooled it
- Steroid hormone profiling reveals altered adrenal androgen production in endometriosis.European journal of endocrinology · 2026Article
- Contribution of endometrial microbiome to inflammation-mediated infertility in women undergoing ART.Human reproduction (Oxford, England) · 2026Article
- Basal androgen status as a modifiable predictor of poor ovarian response in controlled ovarian hyperstimulation.Frontiers in reproductive health · 2026Article
- The serum evaluation of sex hormones including DHEAs, DHT, testosterone in oral lichen planus patients.Scientific reports · 2025Article
- Glucose metabolism and endometrium decidualization.Frontiers in endocrinology · 2025Review
- Connecting the dots: the role of fatigue in female infertility.Reproductive biology and endocrinology : RB&E · 2024Review
- Comparison of the perinatal outcomes of expected high ovarian response patients and normal ovarian response patients undergoing frozen-thawed embryo transfer in natural/small amount of HMG induced ovulation cycles.BMC public health · 2024Article
- Multi-Omics Reveals the Role of Osteopontin/Secreted Phosphoprotein 1 in Regulating Ovarian Aging.Journal of personalized medicine · 2024Article
- Cyclical endometrial repair and regeneration: Molecular mechanisms, diseases, and therapeutic interventions.MedComm · 2023Review
- The effect of obesity on uterine receptivity is mediated by endometrial extracellular vesicles that control human endometrial stromal cell decidualization and trophoblast invasion.Journal of extracellular biology · 2023Article
- Androgen signalling in the ovaries and endometrium.Molecular human reproduction · 2023Review
- Androgen Signaling in Uterine Diseases: New Insights and New Targets.Biomolecules · 2022Review
- A role for steroid 5 alpha-reductase 1 in vascular remodeling during endometrial decidualization.Frontiers in endocrinology · 2022Article
- Impact of Maternal Age on Singleton Birthweight in Frozen Embryo Transfer Cycles.Frontiers in endocrinology · 2022Article
- Female Reproductive Systems: Hormone Dependence and Receptor Expression.Advances in experimental medicine and biology · 2022Article
- Association between paternal age and singleton birthweight in frozen embryo transfer cycles.Reproductive health · 2021Article
- Article
- Interaction between insulin and androgen signalling in decidualization, cell migration and trophoblast invasion in vitro.Journal of cellular and molecular medicine · 2021Article
- The Spiny Mouse-A Menstruating Rodent to Build a Bridge From Bench to Bedside.Frontiers in reproductive health · 2021Review
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveTo investigate the impact of the androgen precursor dehydroepiandrosterone (DHEA) on the decidualization of human endometrial stromal cells isolated from women of advanced reproductive age.
designIn vitro study.
settingUniversity research institute. PATIENT(S): Proliferative phase primary human endometrial stromal fibroblasts (hESFs) were isolated from women of advanced reproductive age (n = 16; mean age, 44.7 ± 2.3). None of the women were receiving hormone therapy or had endometriosis. INTERVENTION(S): Isolated hESFs were decidualized in vitro by incubation with P (1 μM) and cAMP (0.1 mg/mL) in the presence, or absence, of DHEA (10 nM, 100 nM). MAIN OUTCOME MEASURE(S): Secretion of androgens was assessed by ELISA. Expression of decidualization markers and endometrial receptivity markers was assessed by quantitative polymerase chain reaction and ELISA. RESULT(S): Decidualization responses were retained in hESF isolated from women of advanced reproductive age. Supplementation with DHEA increased androgen biosynthesis and concentrations of T and dihydrotestosterone were ∼3× greater after coincubation with DHEA compared with hESF stimulated with decidualization alone. Addition of DHEA to decidualized hESF increased expression of the decidualization markers IGFBP1 and PRL and the endometrial receptivity marker SPP1. DHEA enhanced secretion of IGFBP1, PRL, and SPP1 proteins maximally by day 8 of the decidualization time course concomitant with peak androgen concentrations. CONCLUSION(S): These novel results demonstrate DHEA can enhance in vitro decidualization responses of hESF from women of advanced reproductive age. Supplementation with DHEA during the receptive phase may augment endometrial function and improve pregnancy rates in natural or assisted reproductive cycles.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.