Evidence map›Paper›PMID 29397565›Full record

ArticleNeuroscience bulletin2018

Myt1L Promotes Differentiation of Oligodendrocyte Precursor Cells and is Necessary for Remyelination After Lysolecithin-Induced Demyelination.

Yanqing Shi, Qi Shao, Zhenghao Li, Ginez A Gonzalez, Fengfeng Lu, Dan Wang, Yingyan Pu, Aijun Huang, Chao Zhao, Cheng He and 1 more

Abstract read
In one paragraph

Article in Neuroscience bulletin, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.

  1. MYT1L: A systematic review of genetic variation encompassing schizophrenia and autism.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2020
    Pooled it
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  7. Overexpression ofCurrent issues in molecular biology · 2023
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  11. Melatonin and the Programming of Stem Cells.International journal of molecular sciences · 2022
    Review
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  15. Article
  16. NestoroneCNS neuroscience & therapeutics · 2021
    Article
  17. Article
  18. Article
  19. [Mechanisms underlying remyelination with special focus on demyelination models of multiple sclerosis].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2020
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Yanqing ShiInstitute of Neuroscience, Key Laboratory of Molecular Neurobiology of The Ministry of Education, and The Collaborative Innovation Center for Brain Science, Second Military Medical University, Shanghai, 200433, China.
Qi ShaoInstitute of Neuroscience, Key Laboratory of Molecular Neurobiology of The Ministry of Education, and The Collaborative Innovation Center for Brain Science, Second Military Medical University, Shanghai, 200433, China.
Zhenghao LiInstitute of Neuroscience, Key Laboratory of Molecular Neurobiology of The Ministry of Education, and The Collaborative Innovation Center for Brain Science, Second Military Medical University, Shanghai, 200433, China.
Ginez A GonzalezWellcome Trust-Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge, CB2 0AH, UK.
Fengfeng LuInstitute of Neuroscience, Key Laboratory of Molecular Neurobiology of The Ministry of Education, and The Collaborative Innovation Center for Brain Science, Second Military Medical University, Shanghai, 200433, China.
Dan WangInstitute of Neuroscience, Key Laboratory of Molecular Neurobiology of The Ministry of Education, and The Collaborative Innovation Center for Brain Science, Second Military Medical University, Shanghai, 200433, China.
Yingyan PuInstitute of Neuroscience, Key Laboratory of Molecular Neurobiology of The Ministry of Education, and The Collaborative Innovation Center for Brain Science, Second Military Medical University, Shanghai, 200433, China.
Aijun HuangInstitute of Neuroscience, Key Laboratory of Molecular Neurobiology of The Ministry of Education, and The Collaborative Innovation Center for Brain Science, Second Military Medical University, Shanghai, 200433, China.
Chao ZhaoWellcome Trust-Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge, CB2 0AH, UK.
Cheng HeInstitute of Neuroscience, Key Laboratory of Molecular Neurobiology of The Ministry of Education, and The Collaborative Innovation Center for Brain Science, Second Military Medical University, Shanghai, 200433, China. chenghe@smmu.edu.cn.
Li CaoInstitute of Neuroscience, Key Laboratory of Molecular Neurobiology of The Ministry of Education, and The Collaborative Innovation Center for Brain Science, Second Military Medical University, Shanghai, 200433, China. caoli@smmu.edu.cn.
Second Military Medical University · CNAnhui University · CNMedical Research Council · GBWellcome/MRC Cambridge Stem Cell Institute · GB

Funding

Medical Research Council MR/K008803/1Medical Research Council MR/M010503/1
6 · The paper itself

Abstract

The differentiation and maturation of oligodendrocyte precursor cells (OPCs) is essential for myelination and remyelination in the CNS. The failure of OPCs to achieve terminal differentiation in demyelinating lesions often results in unsuccessful remyelination in a variety of human demyelinating diseases. However, the molecular mechanisms controlling OPC differentiation under pathological conditions remain largely unknown. Myt1L (myelin transcription factor 1-like), mainly expressed in neurons, has been associated with intellectual disability, schizophrenia, and depression. In the present study, we found that Myt1L was expressed in oligodendrocyte lineage cells during myelination and remyelination. The expression level of Myt1L in neuron/glia antigen 2-positive (NG2

Indexed as

AnimalsCell DifferentiationDemyelinating DiseasesLysophosphatidylcholinesMiceMice, Inbred C57BLNerve Tissue ProteinsOligodendrocyte Precursor CellsOligodendrogliaRemyelinationTranscription FactorsLysophosphatidylcholinesMyt1l protein, mouseNerve Tissue ProteinsTranscription FactorsDemyelinationMyt1LOlig1Oligodendrocyte precursor cellsRemyelination

Identifiers

PMID29397565
PMCPMC5856724
OpenAlexW2793262738

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.