Evidence map›Paper›PMID 29397563›Full record

ReviewEating and weight disorders : EWD2018

Insulin resistance in obesity: an overview of fundamental alterations.

Rocco Barazzoni, Gianluca Gortan Cappellari, Maurizio Ragni, Enzo Nisoli

Open access · greenAbstract readReview
PubMed Publisher
In one paragraph

Review in Eating and weight disorders : EWD, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 189 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
189citing papers in PubMed, 6 pooled it
18.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

189 citing papers in PubMed, 6 syntheses or guidelines pooled it, 342 citations in OpenAlex.

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  3. The Role of FacebookInternational journal of environmental research and public health · 2022
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129 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Rocco BarazzoniDepartment of Medical, Surgical and Health Sciences, University of Trieste, Strada di Fiume, 447, 34149, Trieste, Italy. barazzon@units.it.
Gianluca Gortan CappellariDepartment of Medical, Surgical and Health Sciences, University of Trieste, Strada di Fiume, 447, 34149, Trieste, Italy.
Maurizio RagniDepartment of Medical Biotechnology and Translational Medicine, Centre for Study and Research on Obesity, University of Milan, Via Vanvitelli, 32, 20129, Milan, Italy.
Enzo NisoliDepartment of Medical Biotechnology and Translational Medicine, Centre for Study and Research on Obesity, University of Milan, Via Vanvitelli, 32, 20129, Milan, Italy. enzo.nisoli@unimi.it.
University of Milan · ITUniversity of Trieste · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Obesity is a major health risk factor, and obesity-induced morbidity and complications account for huge costs for affected individuals, families, healthcare systems, and society at large. In particular, obesity is strongly associated with the development of insulin resistance, which in turn plays a key role in the pathogenesis of obesity-associated cardiometabolic complications, including metabolic syndrome components, type 2 diabetes, and cardiovascular diseases. Insulin sensitive tissues, including adipose tissue, skeletal muscle, and liver, are profoundly affected by obesity both at biomolecular and functional levels. Altered adipose organ function may play a fundamental pathogenetic role once fat accumulation has ensued. Modulation of insulin sensitivity appears to be, at least in part, related to changes in redox balance and oxidative stress as well as inflammation, with a relevant underlying role for mitochondrial dysfunction that may exacerbate these alterations. Nutrients and substrates as well as systems involved in host-nutrient interactions, including gut microbiota, have been also identified as modulators of metabolic pathways controlling insulin action. This review aims at providing an overview of these concepts and their potential inter-relationships in the development of insulin resistance, with particular regard to changes in adipose organ and skeletal muscle.

Indexed as

Diabetes Mellitus, Type 2HumansInflammationInsulin ResistanceObesityOxidative StressInflammationInsulin resistanceObesityOxidative stress

Identifiers

PMID29397563
OpenAlexW2787302922

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.