Evidence map›Paper›PMID 29397562›Full record

ArticleEating and weight disorders : EWD2019

Intimate stimuli result in fronto-parietal activation changes in anorexia nervosa.

L van Zutphen, S Maier, N Siep, G A Jacob, O Tüscher, L Tebartz van Elst, A Zeeck, A Arntz, M-F O'Connor, H Stamm and 2 more

Abstract read
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In one paragraph

Article in Eating and weight disorders : EWD, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Does Evidence Support an Emotion Regulation Model of Anorexia Nervosa? A Systematic Review of Over a Decade of Research.Clinical psychology : a publication of the Division of Clinical Psychology of the American Psychological Association · 2025
    Article
  2. Review
  3. Article
  4. Article
  5. The Neurobiology of Eating Disorders.Child and adolescent psychiatric clinics of North America · 2019
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

L van ZutphenDepartment of Clinical Psychological Science, Maastricht University, Maastricht, The Netherlands.
S MaierDepartment of Psychosomatic Medicine and Psychotherapy, Medical Center, University of Freiburg Faculty of Medicine, University of Freiburg, Hauptstraße 8, 79104, Freiburg, Germany.
N SiepDepartment of Clinical Psychological Science, Maastricht University, Maastricht, The Netherlands.
G A JacobInstitute of Psychology, University of Freiburg, Freiburg, Germany.
O TüscherDepartment of Psychiatry and Psychotherapy, University of Mainz, Mainz, Germany.
L Tebartz van ElstDepartment of Psychiatry and Psychotherapy, Medical Center, University of Freiburg Faculty of Medicine, University of Freiburg, Freiburg, Germany.
A ZeeckDepartment of Psychosomatic Medicine and Psychotherapy, Medical Center, University of Freiburg Faculty of Medicine, University of Freiburg, Hauptstraße 8, 79104, Freiburg, Germany.
A ArntzDepartment of Clinical Psychological Science, Maastricht University, Maastricht, The Netherlands.
M-F O'ConnorDepartment of Psychology, University of Arizona, Tucson, USA.
H StammDepartment of Psychosomatic Medicine and Psychotherapy, Medical Center, University of Freiburg Faculty of Medicine, University of Freiburg, Hauptstraße 8, 79104, Freiburg, Germany.
M HudekDepartment of Psychosomatic Medicine and Psychotherapy, Medical Center, University of Freiburg Faculty of Medicine, University of Freiburg, Hauptstraße 8, 79104, Freiburg, Germany.
Andreas JoosDepartment of Psychosomatic Medicine and Psychotherapy, Medical Center, University of Freiburg Faculty of Medicine, University of Freiburg, Hauptstraße 8, 79104, Freiburg, Germany. andreas.joos@uniklinik-freiburg.de.ORCID http://orcid.org/0000-0001-6623-4836

Funding

Deutsche Forschungsgemeinschaft JA1785/3-1
6 · The paper itself

Abstract

backgroundIntimacy is a key psychological problem in anorexia nervosa (AN). Empirical evidence, including neurobiological underpinnings, is however, scarce.

objectiveIn this study, we evaluated various emotional stimuli including intimate stimuli experienced in patients with AN and non-patients, as well as their cerebral response.

methodsFunctional magnetic resonance imaging was conducted using stimuli with positive, neutral, negative and intimate content. Participants (14 AN patients and 14 non-patients) alternated between passive viewing and explicit emotion regulation.

resultsIntimate stimuli were experienced less positively in AN patients compared to non-patients. AN patients showed decreased cerebral responses in superior parietal cortices in response to positive and intimate stimuli. Intimate stimuli led to stronger activation of the orbitofrontal cortex, and lower activation of the bilateral precuneus in AN patients. Orbitofrontal responses decreased in AN patients during explicit emotion regulation.

conclusionsThese results show that intimate stimuli are of particular importance in AN patients, who show experiential differences compared to non-patients and altered activation of orbitofrontal and parietal brain structures. This supports that AN patients have difficulties with intimacy, attachment, self-referential processing and body perception. LEVEL OF EVIDENCE: Level III, case-control study.

Indexed as

Emotional RegulationInterpersonal RelationsAnorexia NervosaCase-Control StudiesEmotionsFemaleFrontal LobeFunctional NeuroimagingHumansMagnetic Resonance ImagingParietal LobeYoung AdultAnorexia nervosaEmotion regulationfMRIIntimacyNeuroimagingOrbitofrontal cortexPrecuneus

Identifiers

PMID29397562

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.