ArticleArchives of pharmacal research2018
Finasteride inhibits melanogenesis through regulation of the adenylate cyclase in melanocytes and melanoma cells.
Article in Archives of pharmacal research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 22 citations in OpenAlex.
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- A Study of Sonodynamic Therapy of Melanoma C540 Cells in Vitro by Titania/Gold Nanoparticles.Journal of biomedical physics & engineering · 2024Article
- Logic-based modeling and drug repurposing for the prediction of novel therapeutic targets and combination regimens against E2F1-driven melanoma progression.BMC chemistry · 2023Article
- Discovery and identification of potential anti-melanogenic active constituents of Bletilla striata by zebrafish model and molecular docking.BMC complementary medicine and therapies · 2022Article
- Enhancing Resveratrol Bioproduction and Anti-Melanogenic Activities through Elicitation in DJ526 Cell Suspension.Plants (Basel, Switzerland) · 2021Article
- Physicochemical Characterization of Finasteride Nanosystem for Enhanced Topical Delivery.International journal of nanomedicine · 2021Article
- Genome-scale integrated analysis to identify prospective molecular mechanisms and therapeutic targets in isocitrate dehydrogenase 2 R140Q-mutated acute myeloid leukemia.Oncology reports · 2019Article
- Graminex Pollen: Phenolic Pattern, Colorimetric Analysis and Protective Effects in Immortalized Prostate Cells (PC3) and Rat Prostate Challenged with LPS.Molecules (Basel, Switzerland) · 2018Article
- Drug-Induced Melasma in Patients on 5-Alpha Reductase Inhibitors: A Case Report.Case reports in dermatologyArticle
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Finasteride is a well-known 5α-reductase inhibitor used for treatment of alopecia and prostate cancer. But the effect of finasteride in regulating melanogenesis is still unclear. In the present study the role of finasteride on melanogenesis was investigated. Finasteride decrease melanin level in melanocyte melan-a cells and B16F10 melanoma cells without inducing cytotoxicity. MC1R (melanocortin 1 receptor) protein expression was also inhibited by finasteride thereby decreasing the expression of adenylate cyclase, MITF (Melanogenesis associated transcription factor), tyrosinases, TRP (tyrosinase-related protein) -1 and -2. Thus our study suggest that finasteride inhibits melanogenesis in melanocyte and melanoma cells by inhibiting MC1R.
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