Evidence map›Paper›PMID 29397475›Full record

ArticleThe international journal of cardiovascular imaging2018

Assessment of superficial coronary vessel wall deformation and stress: validation of in silico models and human coronary arteries in vivo.

Xinlei Wu, Clemens von Birgelen, Zehang Li, Su Zhang, Jiayue Huang, Fuyou Liang, Yingguang Li, William Wijns, Shengxian Tu

Abstract readMulticenter StudyValidation Study
PubMed Publisher
In one paragraph

Article in The international journal of cardiovascular imaging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
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  3. Angiography-based radial wall strain in carotid plaques and its association with plaque vulnerability.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2025
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Xinlei WuBiomedical Instrument Institute, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, People's Republic of China.
Clemens von BirgelenDepartment of Cardiology, Thoraxcentrum Twente, Medisch Spectrum Twente, Enschede, The Netherlands.
Zehang LiBiomedical Instrument Institute, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, People's Republic of China.
Su ZhangBiomedical Instrument Institute, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, People's Republic of China.
Jiayue HuangBiomedical Instrument Institute, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, People's Republic of China.
Fuyou LiangSchool of Naval Architecture, Ocean and Civil Engineering, Shanghai Jiao Tong University, Shanghai, People's Republic of China.
Yingguang LiDepartment of Radiology, Leiden University Medical Center, Leiden, The Netherlands.
William WijnsThe Lambe Institute for Translational Medicine and Curam, National University of Ireland, Galway, Ireland.
Shengxian TuBiomedical Instrument Institute, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, People's Republic of China. sxtu@sjtu.edu.cn.
Shanghai Jiao Tong University · CNLeiden University Medical Center · NLMedisch Spectrum Twente · NLOllscoil na Gaillimhe – University of Galway · IE

Funding

National Key Research and Development Program of China 2016YFC0100500National Natural Science Foundation of China 31500797research program from Shanghai Jiao Tong University YG2015ZD04
6 · The paper itself

Abstract

Cyclic biomechanical stress at the lumen-intima interface plays a crucial role in the rupture of coronary plaque. We performed a comprehensive assessment of a novel angiography-based method for four-dimensional (4D) dynamic assessment of superficial wall stress (SWS) and deformation with a total of 32 analyses in virtual stenosis models with equal lumen dimensions and 16 analyses in human coronary arteries in vivo. The in silico model analyses demonstrated that the SWS, derived by the proposed global displacement method without knowledge of plaque components or blood pressure, was comparable with the result calculated by traditional finite element method. Cardiac contraction-induced vessel deformation increased SWS. Softer plaque and positive arterial remodeling, associated with a greater plaque burden, showed more variation in mean lumen diameter within the cardiac cycle and resulted in higher SWS. In vivo patient analyses confirmed the accuracy of computed superficial wall deformation. The centerlines predicted by our method at random selected time instant matched well with the actual one in angiograms by Procrustes analysis (scaling: 0.995 ± 0.018; dissimilarity: 0.007 ± 0.014). Over 50% of the maximum SWS occurred at proximal plaque shoulders. This novel 4D approach could be successfully to predict superficial wall deformation of coronary artery in vivo. The dynamic SWS might be more realistic to evaluate the risk of plaque rupture.

Indexed as

Biomechanical PhenomenaComputer SimulationCoronary AngiographyCoronary Artery DiseaseCoronary StenosisCoronary VesselsFinite Element AnalysisHemodynamicsHumansModels, CardiovascularPilot ProjectsPlaque, AtheroscleroticProspective StudiesRuptureStress, MechanicalComputational biomechanicsCoronary artery diseaseFinite element methodPlaque ruptureSuperficial wall stress

Identifiers

PMID29397475
OpenAlexW2789617808

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.