Evidence map›Paper›PMID 29397450›Full record

ArticleMagma (New York, N.Y.)2018

Segmentation and texture analysis of structural biomarkers using neighborhood-clustering-based level set in MRI of the schizophrenic brain.

Manohar Latha, Ganesan Kavitha

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Article in Magma (New York, N.Y.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

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10citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

2 authors.

Manohar LathaDepartment of Electronics Engineering, Madras Institute of Technology, Chromepet, Chennai, India. lathakaran@gmail.com.ORCID http://orcid.org/0000-0003-2172-7500
Ganesan KavithaDepartment of Electronics Engineering, Madras Institute of Technology, Chromepet, Chennai, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveSchizophrenia (SZ) is a psychiatric disorder that especially affects individuals during their adolescence. There is a need to study the subanatomical regions of SZ brain on magnetic resonance images (MRI) based on morphometry. In this work, an attempt was made to analyze alterations in structure and texture patterns in images of the SZ brain using the level-set method and Laws texture features. MATERIALS AND

methodsT1-weighted MRI of the brain from Center of Biomedical Research Excellence (COBRE) database were considered for analysis. Segmentation was carried out using the level-set method. Geometrical and Laws texture features were extracted from the segmented brain stem, corpus callosum, cerebellum, and ventricle regions to analyze pattern changes in SZ.

resultsThe level-set method segmented multiple brain regions, with higher similarity and correlation values compared with an optimized method. The geometric features obtained from regions of the corpus callosum and ventricle showed significant variation (p < 0.00001) between normal and SZ brain. Laws texture feature identified a heterogeneous appearance in the brain stem, corpus callosum and ventricular regions, and features from the brain stem were correlated with Positive and Negative Syndrome Scale (PANSS) score (p < 0.005).

conclusionA framework of geometric and Laws texture features obtained from brain subregions can be used as a supplement for diagnosis of psychiatric disorders.

Indexed as

Magnetic Resonance ImagingAdultAlgorithmsBiomarkersBrainCluster AnalysisCorpus CallosumFemaleHumansImage Interpretation, Computer-AssistedImage Processing, Computer-AssistedMalePattern Recognition, AutomatedSchizophreniaSoftwareBiomarkersLaws texture featuresLevel setMR brain imagesSchizophrenicSegmentationSubcortical regions

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.