Evidence map›Paper›PMID 29397207›Full record

ArticleJournal of neuroimmunology2018

Cholinergic imbalance in lumbar spinal cord of a rat model of multiple sclerosis.

Chunling Liu, Hui Liu, Hongjun Jin, Xuyi Yue, Zonghua Luo, Zhude Tu

Abstract read
In one paragraph

Article in Journal of neuroimmunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 98% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Dysregulated Cholinergic Signaling Inhibits Oligodendrocyte Maturation Following Demyelination.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Chunling LiuDepartment of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Hui LiuDepartment of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Hongjun JinDepartment of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Xuyi YueDepartment of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Zonghua LuoDepartment of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Zhude TuDepartment of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address: tuz@mir.wustl.edu.
Washington University in St. Louis · US

Funding

PET SPHINGOSINE-1-PHOSPHATE RECEPTOR 1 (S1PR1) RADIOTRACERS FOR MULTIPLE SCLEROSISR01NS103988 · NINDS · WASHINGTON UNIVERSITY · PI Tammie Lee Smith Benzinger, Zhude Tu · 2017 to 2026
$5.3M
PET PROBES FOR IMAGING THE VESICULAR ACETYLCHOLINE TRANSPORTERR01NS075527 · NINDS · WASHINGTON UNIVERSITY · PI TU, ZHUDE · 2011 to 2021
$4.9M
DEVELOPING PET AGENTS FOR IMAGING PHOSPHODIESTERASE 10A (PDE10A)R33MH092797 · NIMH · WASHINGTON UNIVERSITY · PI TU, ZHUDE · 2013 to 2015
$1.5M
DEVELOPMENT OF VESICULAR ACETYLCHOLINE TRANSPORTER IMAGING AGENTS FOR PETR21NS061025 · NINDS · WASHINGTON UNIVERSITY · PI TU, ZHUDE · 2009 to 2010
$628k
DEVELOPING PET AGENTS FOR IMAGING PHOSPHODIESTERASE 10A (PDE10A)R21MH092797 · NIMH · WASHINGTON UNIVERSITY · PI TU, ZHUDE · 2011 to 2012
$530k
NIMH NIH HHS R21 MH092797NIMH NIH HHS R33 MH092797NINDS NIH HHS R01 NS075527NINDS NIH HHS R01 NS103988NINDS NIH HHS R21 NS061025
6 · The paper itself

Abstract

Cholinergic dysfunction in the central nervous system is an important characteristic of multiple sclerosis and experimental autoimmune encephalomyelitis (EAE). By using a rat EAE model, upregulation of vesicular acetylcholine transporter (VAChT) level in the EAE rat lumbar spinal cord was detected by western blot and immunostaining, and was associated with lymphocyte filtration and glial activation. Ex vivo and in vitro autoradiography studies with [

Indexed as

AnimalsDisease ProgressionEncephalomyelitis, Autoimmune, ExperimentalFemaleLymphocytesNeurogliaRatsRats, Inbred LewSpinal CordVesicular Acetylcholine Transport ProteinsSlc18a3 protein, ratVesicular Acetylcholine Transport ProteinsExperimental autoimmune encephalomyelitisNeuroinflammationVesicular acetylcholine transporter

Identifiers

PMID29397207
PMCPMC5880691
OpenAlexW2791500878

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.