Trial reportThe Journal of pediatrics2018
Effect of Dietary Counseling on a Comprehensive Metabolic Profile from Childhood to Adulthood.
Trial report in The Journal of pediatrics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00223600 (Special Turku Atherosclerosis Risk Factor Intervention Project for Children), which is not on this map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Special Turku Atherosclerosis Risk Factor Intervention Project for Children (STRIP)
Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- Nutrition interventions in the first 1000 days and long-term health outcomes: a systematic review.Pediatric research · 2025Pooled it
- Early-Life Nutrition Interventions and Associated Long-Term Cardiometabolic Outcomes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Advances in nutrition (Bethesda, Md.) · 2021Pooled it
- Randomized 20-year infancy-onset dietary intervention, life-long cardiovascular risk factors and retinal microvasculature.European heart journal · 2024Trial
- Achievement of the Targets of the 20-Year Infancy-Onset Dietary Intervention-Association with Metabolic Profile from Childhood to Adulthood.Nutrients · 2021Trial
- Metabolic transition from childhood to adulthood based on two decades of biochemical time series in three longitudinal cohorts.International journal of epidemiology · 2025Article
- Associations of diet quality and food consumption with serum biomarkers for lipid and amino acid metabolism in Finnish children: the PANIC study.European journal of nutrition · 2024Article
- Long-Term Nutritional Counseling for a Patient with Lipoprotein Lipase Deficiency.Journal of atherosclerosis and thrombosis · 2023Article
- Cross-sectionally Calculated Metabolic Aging Does Not Relate to Longitudinal Metabolic Changes-Support for Stratified Aging Models.The Journal of clinical endocrinology and metabolism · 2023Article
- Longitudinal metabolomics of increasing body-mass index and waist-hip ratio reveals two dynamic patterns of obesity pandemic.International journal of obesity (2005) · 2023Observational
- Article
- Prevention of atherosclerosis from childhood.Nature reviews. Cardiology · 2022Review
- Weight gain in infancy and markers of cardiometabolic health in young adulthood.Acta paediatrica (Oslo, Norway : 1992) · 2022Article
- An Infancy-Onset 20-Year Dietary Counselling Intervention and Gut Microbiota Composition in Adulthood.Nutrients · 2022Article
- Lower Intake of Saturated Fatty Acids Is Associated with Improved Lipid Profile in a 6-Year-Old Nationally Representative Population.Nutrients · 2022Article
- Sex hormones drive changes in lipoprotein metabolism.iScience · 2021Article
- Metabolomics in Diabetes and Diabetic Complications: Insights from Epidemiological Studies.Cells · 2021Review
- Nutritional Approach to Prevention and Treatment of Cardiovascular Disease in Childhood.Nutrients · 2021Review
- Circulating metabolites and the risk of type 2 diabetes: a prospective study of 11,896 young adults from four Finnish cohorts.Diabetologia · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 5 institutions in 3 countries.
Funding
Abstract
objectivesTo study the effects of repeated, infancy-onset dietary counseling on a detailed metabolic profile. Effects of dietary saturated fat replacement on circulating concentrations of metabolic biomarkers still remain unknown. STUDY
designThe Special Turku Coronary Risk Factor Intervention Project (STRIP) study is a longitudinal, randomized atherosclerosis prevention trial in which repeated dietary counseling aimed at reducing the proportion of saturated fat intake. Nuclear magnetic resonance metabolomics quantified circulating metabolites from serum samples assessed at age 9 (n = 554), 11 (n = 553), 13 (n = 508), 15 (n = 517), 17 (n = 457), and 19 (n = 417) years.
resultsThe intervention reduced dietary intake of saturated fat (mean difference in daily percentage of total energy intake: -2.1 [95% CI -1.9 to -2.3]) and increased intake of polyunsaturated fat (0.6 [0.5-0.7]). The dietary counseling intervention led to greater serum proportions of polyunsaturated fatty acids (P < .001), with greater proportions of both circulating omega-3 (P = .02) and omega-6 (P < .001) fatty acids. The proportion of saturated fatty acids in serum was lower for both boys and girls in the intervention group (P < .001), whereas the serum proportion of monounsaturated fat was lower for boys in the intervention group only (P < .001). The intervention also reduced circulating intermediate-density lipoprotein and low-density lipoprotein lipid concentrations (P < .01). Dietary intervention effects on nonlipid biomarkers were minor except from greater concentrations of glutamine in the intervention group.
conclusionsRepeated dietary counseling from infancy to early adulthood yielded favorable effects on multiple circulating fatty acids and lipoprotein subclass lipids, particularly in boys. These molecular effects substantiate the beneficial role of saturated fat replacement on the metabolic risk profile.
trial registrationClinicalTrials.gov: NCT00223600.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.