Evidence map›Paper›PMID 29397129›Full record

ArticleBritish journal of anaesthesia2018

Dexmedetomidine promotes metastasis in rodent models of breast, lung, and colon cancers.

H Lavon, P Matzner, A Benbenishty, L Sorski, E Rossene, R Haldar, E Elbaz, J P Cata, V Gottumukkala, S Ben-Eliyahu

Registry-linked trialOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in British journal of anaesthesia, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06030804 (Impact of Perioperative Dexmedetomidine on Long-term Survival in Older Patients After Cancer Surgery), which is not on this map. Cited by 69 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed, 2 pooled it
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06030804 narecruitingnot on this mapstarted 2023, after this paper: background citation

Impact of Perioperative Dexmedetomidine on Long-term Survival in Older Patients After Cancer Surgery: a Multicenter Randomized Trial

TypeinterventionalSponsorPeking University First HospitalRan2023 to 2028Enrolled4,532ConditionsElderly, Cancer Surgery, Dexmedetomidine, Long-Term SurvivorsArmsDexmedetomidine, Placebo
3 · Its place in the literature

Who cites it

69 citing papers in PubMed, 2 syntheses or guidelines pooled it, 116 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Trial
  6. Trial
  7. Trial
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Considerations for Care of the Cancer Patient.International anesthesiology clinics · 2025
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Review

9 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

H LavonSchool of Psychological Sciences, Sharet Building, Tel Aviv University, Tel Aviv, Israel.
P MatznerSchool of Psychological Sciences, Sharet Building, Tel Aviv University, Tel Aviv, Israel.
A BenbenishtySchool of Psychological Sciences, Sharet Building, Tel Aviv University, Tel Aviv, Israel; Sagol School of Neuroscience, Webb Building, Tel Aviv University, Tel Aviv, Israel.
L SorskiSchool of Psychological Sciences, Sharet Building, Tel Aviv University, Tel Aviv, Israel.
E RosseneSchool of Psychological Sciences, Sharet Building, Tel Aviv University, Tel Aviv, Israel.
R HaldarSchool of Psychological Sciences, Sharet Building, Tel Aviv University, Tel Aviv, Israel.
E ElbazSchool of Psychological Sciences, Sharet Building, Tel Aviv University, Tel Aviv, Israel.
J P CataMD Anderson Cancer Center, University of Texas, Houston, TX, USA.
V GottumukkalaMD Anderson Cancer Center, University of Texas, Houston, TX, USA.
S Ben-EliyahuSchool of Psychological Sciences, Sharet Building, Tel Aviv University, Tel Aviv, Israel. Electronic address: shamgar@post.tau.ac.il.
Tel Aviv University · ILThe University of Texas MD Anderson Cancer Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPerioperative strategies can significantly influence long-term cancer outcomes. Dexmedetomidine, an α

methodsDexmedetomidine was given to induce sub-hypnotic to sedative effects for 6-12 h, and its effects on metastasis formation, using various cancer types, were studied in naïve animals and in the context of stress and surgery.

resultsDexmedetomidine increased tumour-cell retention and growth of metastases of a mammary adenocarcinoma (MADB 106) in F344 rats, Lewis lung carcinoma (3LL) in C57BL/6 mice, and colon adenocarcinoma (CT26) in BALB/c mice. The metastatic burden increased in both sexes and in all organs tested, including lung, liver, and kidney, as well as in brain employing a novel external carotid-artery inoculation approach. These effects were mediated through α

conclusionsThe findings call for mechanistic translational studies to understand these deleterious effects of dexmedetomidine, and warrant prospective clinical trials to assess the impact of perioperative dexmedetomidine use on outcomes in cancer patients.

Indexed as

Neoplasm MetastasisAdenocarcinomaAdrenergic alpha-2 Receptor AgonistsAnimalsCarcinoma, Lewis LungColonic NeoplasmsDexmedetomidineFemaleHypnotics and SedativesLung NeoplasmsMaleMammary Neoplasms, ExperimentalMiceMice, Inbred BALB CMice, Inbred C57BLNeoplasms, ExperimentalAdrenergic alpha-2 Receptor AgonistsDexmedetomidineHypnotics and SedativesReceptors, Adrenergic, alpha-2dexmedetomidineneoplasm metastasisperioperative care

Identifiers

PMID29397129
PMCPMC6246773
OpenAlexW2774448570

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.