ArticleJournal of clinical laboratory analysis2018
Maternal thyroid-stimulating hormone reference ranges for first trimester screening from 11 to 14 weeks of gestation.
Article in Journal of clinical laboratory analysis, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.
- Maternal thyroid function in multiple pregnancies - a systematic review.Frontiers in endocrinology · 2022Pooled it
- Global and Indian perspectives on trimester-specific reference intervals for thyroid hormones in pregnant women: a systematic review.Thyroid research · 2026Review
- First-trimester thyroid reference intervals in twin pregnancy: establishment, diagnostic utility, and association with adverse outcomes.Frontiers in endocrinology · 2025Article
- Recommendations of the AGG (Working Group for Obstetrics, Department of Maternal Diseases) on How to Treat Thyroid Function Disorders in Pregnancy.Geburtshilfe und Frauenheilkunde · 2023Article
- Maternal Thyroid Function and Birth Weight in Twins.Endocrinology · 2022Article
- The association between COVID-19 pandemic and maternal isolated hypothyroxinemia in first and second trimesters.Psychoneuroendocrinology · 2021Article
- Thyroid function of twin-pregnant women in early pregnancy.Chinese medical journal · 2019Article
- Maternal thyroid-stimulating hormone reference ranges for first trimester screening from 11 to 14 weeks of gestation.Journal of clinical laboratory analysis · 2018Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo establish maternal thyroid-stimulating hormone (TSH) reference ranges for first trimester screening from 11 + 0 to 13 + 6 weeks of gestation.
methodsA total of 10 592 singleton and 201 twin consecutive Caucasian pregnant women who underwent simultaneously prenatal first trimester Down's syndrome screening and thyroid function screening from January 2010 to November 2017 were included in the study. Women with positive antithyroid peroxidase antibody (TPOAb) and positive personal history of thyroid disease were previously excluded. TSH was measured by immunochemiluminescent assay on ci 16200 Abbott Architect analyzer. Nonparametric percentile method (also known as CLSI C28.A3) was used for the determination of reference ranges.
resultsWe established reference ranges of TSH for the period of gestation from 11 + 0 to 13 + 6 weeks of pregnancy as 0.16-3.43 mU/L for singleton Caucasian pregnancies and 0.02-2.95 mU/L for twin Caucasian pregnancies. The median (IQR) of TSH for singleton pregnancies was higher than that for twin pregnancies (1.25 mU/L (0.83-1.81) vs 0.84 (0.37-1.47), respectively; P < .0001).
conclusionsEach first trimester screening center should be aware of which type of immunoassay their laboratory uses. TSH reference ranges in women during the first trimester of pregnancy are lower than those for general population. Twin pregnancies have lower TSH than singleton pregnancies.
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