Observational studyDiabetologia2018
The Adolescent Cardio-Renal Intervention Trial (AdDIT): retinal vascular geometry and renal function in adolescents with type 1 diabetes.
Observational study in Diabetologia, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Blood pressure control for diabetic retinopathy.The Cochrane database of systematic reviews · 2023Pooled it
- Association of Retinal Microangiopathy with Albuminuria in Patient with Chronic Kidney Disease: a Meta-analysis Study.Medical archives (Sarajevo, Bosnia and Herzegovina) · 2023Pooled it
- Retinal Vascular Geometry in Hypertension: cSLO-Based Method.Ophthalmology and therapy · 2023Article
- Development and validation of a diabetic retinopathy risk prediction model for middle-aged patients with type 2 diabetes mellitus.Frontiers in endocrinology · 2023Article
- Observational
- Early microvascular complications in type 1 and type 2 diabetes: recent developments and updates.Pediatric nephrology (Berlin, Germany) · 2022Review
- Retinal Vascular Signs as Screening and Prognostic Factors for Chronic Kidney Disease: A Systematic Review and Meta-Analysis of Current Evidence.Journal of personalized medicine · 2021Review
- Imaging the eye and its relevance to diabetes care.Journal of diabetes investigation · 2021Review
- A new strategy for vascular complications in young people with type 1 diabetes mellitus.Nature reviews. Endocrinology · 2019Review
- Management of diabetes complications in youth.Therapeutic advances in endocrinology and metabolism · 2019Review
- A narrative review of retinal vascular parameters and the applications (Part I): Measuring methods.Brain circulationReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
Abstract
aims/hypothesisWe examined the hypothesis that elevation in urinary albumin creatinine ratio (ACR) in adolescents with type 1 diabetes is associated with abnormal retinal vascular geometry (RVG) phenotypes.
methodsA cross-sectional study at baseline of the relationship between ACR within the normoalbuminuric range and RVG in 963 adolescents aged 14.4 ± 1.6 years with type 1 diabetes (median duration 6.5 years) screened for participation in AdDIT. A validated algorithm was used to categorise log
resultsGreater log CONCLUSIONS/
interpretationHigher ACR in adolescents is associated with narrower and more tortuous retinal vessels. Therefore, RVG phenotypes may serve to identify populations at high risk of diabetes complications during adolescence and well before onset of clinical diabetes complications.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.