Evidence map›Paper›PMID 29396640›Full record

ReviewDer Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete2018

[Neurophysiology of atopic pruritus].

N H Meyer, B Gibbs, M Schmelz, B Homey, U Raap

Abstract readReview
PubMed Publisher
In one paragraph

Review in Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. [Atopic eczema].Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

N H MeyerDepartment für Humanmedizin, Universitätsklinik für Dermatologie und Allergie, Universität Oldenburg, Rahel-Straus-Str. 10, 26133, Oldenburg, Deutschland.
B GibbsDepartment für Humanmedizin, Universitätsklinik für Dermatologie und Allergie, Universität Oldenburg, Rahel-Straus-Str. 10, 26133, Oldenburg, Deutschland.
M SchmelzExperimentelle Schmerzforschung, Medizinische Fakultät Mannheim, Universität Heidelberg, Heidelberg, Deutschland.
B HomeyDept. für Dermatologie und Allergologie, Universität Düsseldorf, Düsseldorf, Deutschland.
U RaapDepartment für Humanmedizin, Universitätsklinik für Dermatologie und Allergie, Universität Oldenburg, Rahel-Straus-Str. 10, 26133, Oldenburg, Deutschland. Ulrike.Raap@uni-oldenburg.de.
Carl von Ossietzky Universität Oldenburg · DEHeidelberg University · DEHeinrich Heine University Düsseldorf · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pruritus is one of the major symptoms of inflammatory skin diseases and strongly affects the quality of life in patients. Although the perception of pruritus and pain are closely intertwined, pruritus represents a distinct sensation, which is also significantly different to pain at a neurophysiological level. The pathophysiological basis of chronic and acute pruritus is not fully understood. Besides histamine, a plethora of different neuromediators of itch, including neurotrophins, neuropeptides and their corresponding receptors, have been identified. In atopic dermatitis the release of these mediators leads to an activation of immune cells, such as mast cells and eosinophilic granulocytes, which in turn release neuromediators and cytokines that activate peripheral neurons. This review focuses on the neurophysiological interactions which regulate pruritus and summarizes the function of neurological and inflammatory mediators in atopic pruritus.

Indexed as

CytokinesDermatitis, AtopicEosinophilsHumansInflammationNerve Growth FactorsNeuropeptidesNeurotransmitter AgentsPruritusReceptors, NeurotransmitterSkinCytokinesNerve Growth FactorsNeuropeptidesNeurotransmitter AgentsReceptors, NeurotransmitterAtopic dermatitisCytokinesEosinophilic granulocytesNeuropeptidesNeurotrophins

Identifiers

PMID29396640
OpenAlexW2794150643

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.