ArticleEuropean journal of nuclear medicine and molecular imaging2018
Amyloid and tau signatures of brain metabolic decline in preclinical Alzheimer's disease.
Article in European journal of nuclear medicine and molecular imaging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Higher educational attainment, accelerated tau, and slower decline: unraveling the Alzheimer's paradox.European radiology · 2026Article
- Observational
- Plasma GFAP for populational enrichment of clinical trials in preclinical Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Review
- Review
- The use of individual-based FDG-PET volume of interest in predicting conversion from mild cognitive impairment to dementia.BMC medical imaging · 2024Article
- A cross-scanner and cross-tracer deep learning method for the recovery of standard-dose imaging quality from low-dose PET.European journal of nuclear medicine and molecular imaging · 2022Article
- Longitudinal 18F-MK-6240 tau tangles accumulation follows Braak stages.Brain : a journal of neurology · 2021Article
- Microglial activation and tau propagate jointly across Braak stages.Nature medicine · 2021Article
- Biphasic cortical macro- and microstructural changes in autosomal dominant Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2021Article
- Periodontal dysbiosis associates with reduced CSF Aβ42 in cognitively normal elderly.Alzheimer's & dementia (Amsterdam, Netherlands) · 2021Article
- CSF TNF-α Levels Were Associated with Longitudinal Change in Brain Glucose Metabolism Among Non-Demented Older People.Neuropsychiatric disease and treatment · 2021Article
- Single and Combined Neuroimaging Techniques for Alzheimer's Disease Detection.Computational intelligence and neuroscience · 2021Review
- Cohort-Specific Optimization of Models Predicting Preclinical Alzheimer's Disease, to Enhance Screening Performance in the Middle of Preclinical Alzheimer's Disease Clinical Studies.The journal of prevention of Alzheimer's disease · 2021Article
- 3D-Deep Learning Based Automatic Diagnosis of Alzheimer's Disease with Joint MMSE Prediction Using Resting-State fMRI.Neuroinformatics · 2020Article
- Topographical distribution of Aβ predicts progression to dementia in Aβ positive mild cognitive impairment.Alzheimer's & dementia (Amsterdam, Netherlands) · 2020Article
- Late-stage Anle138b treatment ameliorates tau pathology and metabolic decline in a mouse model of human Alzheimer's disease tau.Alzheimer's research & therapy · 2019Article
- Poster Viewing Sessions PA00-A01 to PA00-A49.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2019Article
- Aβ-induced vulnerability propagates via the brain's default mode network.Nature communications · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
purposeWe aimed to determine the amyloid (Aβ) and tau biomarker levels associated with imminent Alzheimer's disease (AD) - related metabolic decline in cognitively normal individuals.
methodsA threshold analysis was performed in 120 cognitively normal elderly individuals by modelling 2-year declines in brain glucose metabolism measured with [
resultsThe combination of [
conclusionsThese results highlight the new concept that combined Aβ and tau thresholds can predict imminent neurodegeneration as an alternative framework with a high statistical power for testing the effect of disease-modifying therapies on [
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.