ArticleScientific reports2018
First identification of marine diatoms with anti-tuberculosis activity.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 39 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
39 citing papers in PubMed.
- Arctic Diatoms as a Source of Antibiofilm Compounds: Identification of Methyl 3-Hydroxyoctadecanoate and PheophorbideBiomolecules · 2025Article
- In-vitro assessment and characterization of anticancer, antibacterial, and antioxidant activity of diatom-derived metabolites.Scientific reports · 2025Article
- Harnessing Microalgae as Sustainable Cell Factories for Polyamine-Based Nanosilica for Biomedical Applications.Molecules (Basel, Switzerland) · 2025Review
- Antiviral Activity of the Marine HaptophytaMarine drugs · 2024Article
- Screening of Microalgae for Bioactivity with Antiviral, Antibacterial, Anti-Inflammatory and Anti-Cancer Assays.Biology · 2024Article
- Review
- Study of the Antimicrobial Potential of theMarine drugs · 2023Article
- Article
- Microbial Interactions between Marine Microalgae and Fungi: From Chemical Ecology to Biotechnological Possible Applications.Marine drugs · 2023Review
- Biotechnological product potential of Auxenochlorella protothecoides including biologically active compounds (BACs) under nitrogen stress conditions.World journal of microbiology & biotechnology · 2023Article
- Transcriptome Sequencing of the DiatomMarine drugs · 2023Article
- ExploringMarine drugs · 2022Article
- Research Progresses on the Physiological and Pharmacological Benefits of Microalgae-Derived Biomolecules.Foods (Basel, Switzerland) · 2022Review
- De Novo Transcriptome of the FlagellateBiology · 2022Article
- Recent Antimicrobial Responses of Halophilic Microbes in Clinical Pathogens.Microorganisms · 2022Review
- Editorial of Special Issue "Microalgal Molecules and Enzymes".International journal of molecular sciences · 2021Article
- Recent advances in the discovery of novel marine natural products and mycosporine-like amino acid UV-absorbing compounds.Applied microbiology and biotechnology · 2021Review
- Phytoplankton of the Curonian Lagoon as a New Interesting Source for Bioactive Natural Products. Special Impact on Cyanobacterial Metabolites.Biomolecules · 2021Article
- Promising Activities of Marine Natural Products against Hematopoietic Malignancies.Biomedicines · 2021Review
- Unlocking the Health Potential of Microalgae as Sustainable Sources of Bioactive Compounds.International journal of molecular sciences · 2021Review
Corrections and comments
- Erratum issued
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Marine microalgae are considered a potentially new and valuable source of biologically active compounds for applications in several biotechnology sectors. They can be easily cultured, have short generation times and enable an environmentally-friendly approach to drug discovery by overcoming problems associated with the over-utilization of marine resources and the use of destructive collection practices. Considering the increasing rate of antibiotic-resistance bacteria and infections by fungi, 46 microalgae have been screened in this study for possible antibacterial and antifungal activities. Two different extraction methods have been used in order to increase the probability of finding positive hits. In particular, we screened microalgae in both control and nutrient stress conditions. We also tested different strains for 7 species in order to study potentially different bioactivities due to strain diversity. Results showed that extracts of two diatoms, Skeletonema tropicum and Chaetoceros pseudocurvisetus, had anti-tuberculosis activity and were active only when cultured in the control and phosphate-starvation conditions, while the nitrogen starvation condition showed no activity. In addition, we tested both the organic and water extracts and found that only the organic extracts for both diatoms were active. The organic extracts of these two diatom species were not toxic on normal human cell lines.
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Registered trials
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