Evidence map›Paper›PMID 29396481›Full record

ArticleScientific reports2018

Conserved DNA Methylation Signatures in Early Maternal Separation and in Twins Discordant for CO

Francesca Giannese, Alessandra Luchetti, Giulia Barbiera, Valentina Lampis, Claudio Zanettini, Gun Peggy Knudsen, Simona Scaini, Dejan Lazarevic, Davide Cittaro, Francesca R D'Amato and 1 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04181008 (Pharmacokinetics of Amiloride Nasal Spray in Healthy Volunteers), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04181008 early_phase1completednot on this mapstarted 2020, after this paper: background citation

Pharmacokinetics of Amiloride Nasal Spray in Healthy Volunteers

TypeinterventionalSponsorUniversity of UtahRan2020 to 2023Enrolled15ConditionsPharmacokineticsArmsAmiloride
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 16 citations in OpenAlex.

  1. Population Pharmacokinetics of Intranasal Amiloride in Healthy Volunteers.European journal of drug metabolism and pharmacokinetics · 2026
    Trial
  2. Pharmacokinetics of intranasal amiloride in healthy volunteers.Clinical and translational science · 2023
    Trial
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 4 countries.

Francesca GianneseCentre for Translational Genomics and Bioinformatics, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), San Raffaele Scientific Institute, Milan, Italy.
Alessandra LuchettiInstitute of Cell Biology and Neurobiology, National Research Council, Rome, Italy.
Giulia BarbieraCentre for Translational Genomics and Bioinformatics, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), San Raffaele Scientific Institute, Milan, Italy.
Valentina LampisDepartment of Oncology, University of Milan, Milan, Italy.
Claudio ZanettiniInstitute of Cell Biology and Neurobiology, National Research Council, Rome, Italy.
Gun Peggy KnudsenThe Norwegian Institute of Public Health Department of Genetics, Environment and Mental Health, Oslo, Norway.
Simona ScainiDepartment of Psychology, Sigmund Freud University, Milan, Italy.
Dejan LazarevicCentre for Translational Genomics and Bioinformatics, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), San Raffaele Scientific Institute, Milan, Italy.
Davide CittaroCentre for Translational Genomics and Bioinformatics, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), San Raffaele Scientific Institute, Milan, Italy.ORCID http://orcid.org/0000-0003-0384-3700
Francesca R D'AmatoInstitute of Cell Biology and Neurobiology, National Research Council, Rome, Italy. francesca.damato@cnr.it.
Marco BattagliaDepartment of Psychiatry, the University of Toronto, Toronto, Canada. Marco.Battaglia@camh.ca.
Istituti di Ricovero e Cura a Carattere Scientifico · ITNational Research Council · ITCentre for Addiction and Mental Health · CANational Institute on Drug Abuse · USNorwegian Institute of Public Health · NOSigmund Freud Privatuniversität - Standort Mailand · ITUniversity of Milan · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Respiratory and emotional responses to blood-acidifying inhalation of CO

Indexed as

DNA MethylationEpigenesis, GeneticAnimalsBrainCarbon DioxideHumansHydrogen-Ion ConcentrationMiceTwins, MonozygoticCarbon Dioxide

Identifiers

PMID29396481
PMCPMC5797081
OpenAlexW2807613615

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.