ArticleScientific reports2018
Nanodiamonds-induced effects on neuronal firing of mouse hippocampal microcircuits.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Toward Subcellular Action Potential Detection with Nanodiamond Quantum Magnetometry.Nanomaterials (Basel, Switzerland) · 2025Article
- Chemically Anchored Diamond with H3 Centers for Ratiometric Measurement of Isolated Mitochondria Temperature.International journal of molecular sciences · 2025Article
- Effects of Thermal Oxidation and Proton Irradiation on Optically Detected Magnetic Resonance Sensitivity in Sub-100 nm Nanodiamonds.ACS applied materials & interfaces · 2025Article
- Smart Polymeric 3D Microscaffolds Hosting Spheroids for Neuronal Research via Quantum Metrology.Advanced healthcare materials · 2025Article
- Functionalized Nanodiamonds for Targeted Neuronal Electromagnetic Signal Detection.ACS applied materials & interfaces · 2024Article
- Review
- Limitations of Bulk Diamond Sensors for Single-Cell Thermometry.Sensors (Basel, Switzerland) · 2023Article
- Nanodiamond-Quantum Sensors Reveal Temperature Variation Associated to Hippocampal Neurons Firing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Article
- Interaction of Nanodiamonds with Water: Impact of Surface Chemistry on Hydrophilicity, Aggregation and Electrical Properties.Nanomaterials (Basel, Switzerland) · 2021Article
- Quantal Release of Dopamine and Action Potential Firing Detected in Midbrain Neurons by Multifunctional Diamond-Based Microarrays.Frontiers in neuroscience · 2019Article
- Graphitic and oxidised high pressure high temperature (HPHT) nanodiamonds induce differential biological responses in breast cancer cell lines.Nanoscale · 2018Article
Corrections and comments
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Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fluorescent nanodiamonds (FND) are carbon-based nanomaterials that can efficiently incorporate optically active photoluminescent centers such as the nitrogen-vacancy complex, thus making them promising candidates as optical biolabels and drug-delivery agents. FNDs exhibit bright fluorescence without photobleaching combined with high uptake rate and low cytotoxicity. Focusing on FNDs interference with neuronal function, here we examined their effect on cultured hippocampal neurons, monitoring the whole network development as well as the electrophysiological properties of single neurons. We observed that FNDs drastically decreased the frequency of inhibitory (from 1.81 Hz to 0.86 Hz) and excitatory (from 1.61 to 0.68 Hz) miniature postsynaptic currents, and consistently reduced action potential (AP) firing frequency (by 36%), as measured by microelectrode arrays. On the contrary, bursts synchronization was preserved, as well as the amplitude of spontaneous inhibitory and excitatory events. Current-clamp recordings revealed that the ratio of neurons responding with AP trains of high-frequency (fast-spiking) versus neurons responding with trains of low-frequency (slow-spiking) was unaltered, suggesting that FNDs exerted a comparable action on neuronal subpopulations. At the single cell level, rapid onset of the somatic AP ("kink") was drastically reduced in FND-treated neurons, suggesting a reduced contribution of axonal and dendritic components while preserving neuronal excitability.
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