Evidence map›Paper›PMID 29396452›Full record

ArticleScientific reports2018

Polymerization-Induced Phase Separation Formation of Structured Hydrogel Particles via Microfluidics for Scar Therapeutics.

S Guo, G Kang, D T Phan, M N Hsu, Y C Por, C H Chen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.3field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 35 citations in OpenAlex.

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  15. Biomaterials to Prevent Post-Operative Adhesion.Materials (Basel, Switzerland) · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

S GuoDepartment of Biomedical Engineering, National University of Singapore, 4 Engineering Drive 3, 117583, Singapore, Singapore.
G KangDepartment of Plastic, Reconstructive & Aesthetic Surgery, KK Women's and Children's Hospital, 100 Bukit Timah Rd, 229899, Singapore, Singapore.
D T PhanDepartment of Biomedical Engineering, National University of Singapore, 4 Engineering Drive 3, 117583, Singapore, Singapore.
M N HsuDepartment of Biomedical Engineering, National University of Singapore, 4 Engineering Drive 3, 117583, Singapore, Singapore.
Y C PorDepartment of Plastic, Reconstructive & Aesthetic Surgery, KK Women's and Children's Hospital, 100 Bukit Timah Rd, 229899, Singapore, Singapore.
C H ChenDepartment of Biomedical Engineering, National University of Singapore, 4 Engineering Drive 3, 117583, Singapore, Singapore. biecch@nus.edu.sg.
National University of Singapore · SGKK Women's and Children's Hospital · SG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Excessive scar formation can form disabling contractures that result in a debilitating psychological outcome. Sustainable hydrophobic corticosteroid release in vivo is essential to regulate the wound healing process. Functional hydrogel particles are widely applied for sustainable release. However, due to the limited aqueous solubility of hydrophobic compounds, most of the corticosteroid is released from the hydrogels within seconds, causing undesirable scar formation and recurrence. In this study, a novel polymerization-induced phase separation is investigated to form well-defined polyethylene glycol diacrylate (PEGDA) core/alginate shell structured hydrogel particles using microfluidics without toxic organic solvents. Based on their wettability preference, hydrophobic corticosteroid-loaded poly(lactic-co-glycolic acid) (PLGA) nanoparticles are compartmentalized in the PEGDA core during polymerization to control the corticosteroid release. The distribution of the PLGA nanoparticles is precisely regulated by the phase separation boundary and characterized using a fluorescent dye. The thickness of the shell and partition coefficients are determined using the UV intensity and irradiation period. Upon encapsulation of the PLGA nanoparticles within the poly(PEGDA) core, a long-term corticosteroid treatment is developed and effective scar therapeutic outcomes are evaluated using both in vitro and in vivo models.

Indexed as

Adrenal Cortex HormonesAnimalsCicatrixDrug CarriersFemaleHydrogel, Polyethylene Glycol DimethacrylateHydrogelsHydrophobic and Hydrophilic InteractionsMicrofluidicsNanoparticlesPolylactic Acid-Polyglycolic Acid CopolymerRabbitsWound HealingAdrenal Cortex HormonesDrug CarriersHydrogel, Polyethylene Glycol DimethacrylateHydrogelsPolylactic Acid-Polyglycolic Acid Copolymer

Identifiers

PMID29396452
PMCPMC5797090
OpenAlexW2799923331

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.