ArticleScientific reports2018
Ventromedial prefrontal cortex mediates sex differences in persistent cognitive drive for food.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 25 citations in OpenAlex.
- Adolescent and adult age differences in palatable food learning and consumption.Physiology & behavior · 2025Article
- Impact of satiety on palatable food associative learning and consumption in male and female adult rats.Physiology & behavior · 2025Article
- Adolescent mice exhibit lower reward sensitivity than adults.Frontiers in behavioral neuroscience · 2025Article
- Recruitment of hippocampal and thalamic pathways to the central amygdala in the control of feeding behavior under novelty.Brain structure & function · 2024Article
- Stress and sex-dependent effects on conditioned inhibition of fear.Learning & memory (Cold Spring Harbor, N.Y.) · 2022Article
- Corticostriatal Suppression of Appetitive Pavlovian Conditioned Responding.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Sex differences in the immediate extinction deficit and renewal of extinguished fear in rats.PloS one · 2022Article
- Chemogenetic selective manipulation of nucleus accumbens medium spiny neurons bidirectionally controls alcohol intake in male and female rats.Scientific reports · 2020Article
- Medial Prefrontal Cortex Neural Plasticity, Orexin Receptor 1 Signaling, and Connectivity with the Lateral Hypothalamus Are Necessary in Cue-Potentiated Feeding.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Comparing ABA, AAB, and ABC Renewal of Appetitive Pavlovian Conditioned Responding in Alcohol- and Sucrose-Trained Male Rats.Frontiers in behavioral neuroscience · 2020Article
- Feeding Behavior Survival Circuit: Anticipation & Competition.Current opinion in behavioral sciences · 2018Article
- Distinct recruitment of the hippocampal, thalamic, and amygdalar neurons projecting to the prelimbic cortex in male and female rats during context-mediated renewal of responding to food cues.Neurobiology of learning and memory · 2018Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Contemporary environments are saturated with food cues that stimulate appetites in the absence of hunger, which leads to maladaptive eating. These settings can induce persistent drive to eat, as learned behaviors can reappear after extinction. Behavioral paradigms of responding renewal provide a valuable framework to study how food cues contribute to the inability to resist palatable foods and change maladaptive eating habits. Using a rat model for this persistent food motivation, we determined sex differences in the causal function for the ventromedial prefrontal cortex (vmPFC) during context-mediated renewal of responding to food cues. Previously, we found behavioral sex differences (only males exhibited renewal) and differential recruitment within the vmPFC (increased Fos induction in males but decreased in females). Here, we used DREADDs (Designer Receptors Exclusively Activated by Designer Drugs) to silence vmPFC neurons in males and to stimulate vmPFC neurons in females specifically during renewal. Silencing vmPFC neurons in males disrupted renewal of responding to a food cue, while stimulating vmPFC neurons in females induced this behavior. These findings demonstrate sex differences in the vmPFC function in a model of food seeking relevant to environmentally driven appetites contributing to obesity and eating disorders.
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Registered trials
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