ArticleScientific reports2018
Associations between serum polybrominated diphenyl ethers and thyroid hormones in a cross sectional study of a remote Alaska Native population.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- A Systematic Review of Environmental Health Outcomes in Selected American Indian and Alaska Native Populations.Journal of racial and ethnic health disparities · 2020Pooled it
- Polybrominated Diphenyl Ethers, Occupational Exposures, and Thyroid Function Among US and Canadian Firefighters: A Cross-sectional Study.Journal of occupational and environmental medicine · 2025Article
- A prospective cohort study of persistent endocrine-disrupting chemicals and perceived stress.American journal of epidemiology · 2024Article
- Health effects associated with measured contaminants in the Arctic: short communication.International journal of circumpolar health · 2024Article
- Key recommendations and research priorities of the 2021 AMAP human health assessment.International journal of circumpolar health · 2024Article
- A Review of the Association between Exposure to Flame Retardants and Thyroid Function.Biomedicines · 2024Review
- The potential of micro- and nanoplastics to exacerbate the health impacts and global burden of non-communicable diseases.Cell reports. Medicine · 2024Review
- Bromine contamination and risk management in terrestrial and aquatic ecosystems.Journal of hazardous materials · 2024Review
- Differential gene expression and developmental pathologies associated with persistent organic pollutants in sentinel fish in Troutman Lake, Sivuqaq, Alaska.Environmental pollution (Barking, Essex : 1987) · 2024Article
- Update of the risk assessment of polybrominated diphenyl ethers (PBDEs) in food.EFSA journal. European Food Safety Authority · 2024Article
- Endocrine disrupting and carcinogenic effects of decabromodiphenyl ether.Frontiers in endocrinology · 2023Review
- Mechanisms of Male Reproductive Toxicity of Polybrominated Diphenyl Ethers.International journal of molecular sciences · 2022Review
- Polybrominated Diphenyl Ethers (PBDEs) in Marine Fish and Dietary Exposure in Newfoundland.EcoHealth · 2022Article
- Environmental Factors Affecting Thyroid-Stimulating Hormone and Thyroid Hormone Levels.International journal of molecular sciences · 2021Review
- Polybrominated Diphenyl Ether Serum Concentrations and Depressive Symptomatology in Pregnant African American Women.International journal of environmental research and public health · 2021Article
- Dietary Intake of Endocrine Disrupting Substances Presents in Environment and Their Impact on Thyroid Function.Nutrients · 2021Review
- Combining Network Pharmacology with Molecular Docking for Mechanistic Research on Thyroid Dysfunction Caused by Polybrominated Diphenyl Ethers and Their Metabolites.BioMed research international · 2021Article
- Structural studies on the endocrine-disrupting role of polybrominated diphenyl ethers (PBDEs) in thyroid diseases.Environmental science and pollution research international · 2020Article
- Polybrominated diphenyl ether (PBDE) and poly- and perfluoroalkyl substance (PFAS) exposures during pregnancy and maternal depression.Environment international · 2020Article
- A State-of-the-Art Review of Indigenous Peoples and Environmental Pollution.Integrated environmental assessment and management · 2020Review
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
Polybrominated diphenyl ethers (PBDEs) are ubiquitous environmental pollutants. Arctic indigenous peoples are exposed to PBDEs through a traditional diet high in marine mammals. PBDEs disrupt thyroid homeostasis. The aim of this study was to assess the relationship between serum PBDEs and thyroid function in a remote population of St. Lawrence Island Yupik. Serum samples were collected from 85 individuals from St. Lawrence Island, Alaska and measured for concentrations of PBDEs, free and total thyroxine (T4), free and total triiodothyronine (T3), and thyroid stimulating hormone (TSH). The relationships between PBDEs and thyroid hormones were assessed using multiple linear regression fit with generalized estimating equations. Serum concentrations of several Penta-BDE congeners (BDE-28/33, 47, and 100) were positively associated with concentrations of TSH and free T3, while serum concentration of BDE-153 was negatively associated with total T3 concentrations. Both BDE-47 and 153 remained significantly associated with thyroid hormones when BDE-47, BDE-153, and BDE-209 were covariates in the same model. There were no significant relationships between serum concentrations of PBDEs and either free or total T4. Individual PBDEs are associated with thyroid hormones in serum from a remote population of Alaska Natives, and directions of effect differ by congener.
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