ArticleNature communications2018
Discordant congenital Zika syndrome twins show differential in vitro viral susceptibility of neural progenitor cells.
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Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 78 papers.
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78citing papers in PubMed
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78 citing papers in PubMed.
- Zika exposure during pregnancy and the risk of hospitalisation and death due to community-acquired pneumonia in early childhood: a nationwide registry-based cohort study in Brazil.Lancet regional health. Americas · 2026Article
- Co-Expression Network Analyses Reveal Long Non-Coding RNA Programs Associated with Trophoblast Development and Response to Zika Virus Infection in Twins Discordant for Congenital Zika Syndrome.International journal of molecular sciences · 2026Article
- West Nile virus and Zika virus infections induce aggresome formation in human neural progenitor and A549 cells.Journal of virology · 2026Article
- Interleukin-27 is antiviral against Zika virus at the maternal-fetal interface.Nature communications · 2025Article
- A Scoping Review of Genetic Risk Factors Possibly Impacting Virally Induced Brain Injury After Zika Infection.Pediatric research · 2025Article
- Zika Virus: A Tale of Two Lineages.Pathogens (Basel, Switzerland) · 2025Review
- Building a growing genomic repository for maternal and fetal health through the PING Consortium.Pediatric research · 2025Article
- Genetic variants underlying congenital Zika syndrome and severe microcephaly: a systematic review and meta-analysis.Virusdisease · 2025Article
- Multi-omics analysis reveals key immunogenic signatures induced by oncolytic Zika virus infection of paediatric brain tumour cells.Scientific reports · 2025Article
- Congenital Zika virus infection in laboratory animals: a comparative review highlights translational studies on the maternal-foetal interface.Memorias do Instituto Oswaldo Cruz · 2025Review
- Identification of natural Zika virus peptides presented on the surface of paediatric brain tumour cells by HLA class I.PloS one · 2025Article
- Zika virus vertical transmission induces neuroinflammation and synapse impairment in brain cells derived from children born with Congenital Zika Syndrome.Scientific reports · 2024Article
- Genetically modified ZIKA virus as a microRNA-sensitive oncolytic virus against central nervous system tumors.Molecular therapy : the journal of the American Society of Gene Therapy · 2024Article
- Zika Virus Infection Alters the Circadian Clock Expression in Human Neuronal Monolayer and Neurosphere Cultures.Cellular and molecular neurobiology · 2023Article
- Insights into Zika Virus Pathogenesis and Potential Therapeutic Strategies.Biomedicines · 2023Review
- ZIKV infection differentially affects the transcriptional profiles in HTR8 and U251 cells.Virus research · 2023Article
- Noncoding RNA of Zika Virus Affects Interplay between Wnt-Signaling and Pro-Apoptotic Pathways in the Developing Brain Tissue.Viruses · 2023Article
- Association between genetic variants in TREM1, CXCL10, IL4, CXCL8 and TLR7 genes with the occurrence of congenital Zika syndrome and severe microcephaly.Scientific reports · 2023Article
- Stem Cell Technology in Organ Transplantation: A Novel Method for 3D Bioprinting Functional and Stable Liver Grafts Using Human iPS Cells Derived Cells.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Recurrence of COVID-19 associated with reduced T-cell responses in a monozygotic twin pair.Open biology · 2022Article
18 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
42 authors.
Luiz Carlos Caires-JúniorDepartment of Genetics and Evolutionary Biology, Human Genome and Stem Cell Research Center, Biosciences Institute, University of São Paulo (USP), São Paulo - SP, 05508-900, Brazil.
Ernesto GoulartDepartment of Genetics and Evolutionary Biology, Human Genome and Stem Cell Research Center, Biosciences Institute, University of São Paulo (USP), São Paulo - SP, 05508-900, Brazil.
Uirá Souto MeloDepartment of Genetics and Evolutionary Biology, Human Genome and Stem Cell Research Center, Biosciences Institute, University of São Paulo (USP), São Paulo - SP, 05508-900, Brazil.
Bruno Henrique Silva AraujoBrazilian Biosciences National Laboratory (LNBio), Brazilian Center for Research in Energy and Materials (CNPEM), Campinas - SP, 13083-970, Brazil.ORCID http://orcid.org/0000-0003-0012-4217
Lucas AlviziDepartment of Genetics and Evolutionary Biology, Human Genome and Stem Cell Research Center, Biosciences Institute, University of São Paulo (USP), São Paulo - SP, 05508-900, Brazil.
Alessandra Soares-SchanoskiButantan Institute, São Paulo - SP, 05503-900, Brazil.
Danyllo Felipe de OliveiraDepartment of Genetics and Evolutionary Biology, Human Genome and Stem Cell Research Center, Biosciences Institute, University of São Paulo (USP), São Paulo - SP, 05508-900, Brazil.
Gerson Shigeru KobayashiDepartment of Genetics and Evolutionary Biology, Human Genome and Stem Cell Research Center, Biosciences Institute, University of São Paulo (USP), São Paulo - SP, 05508-900, Brazil.
Karina Griesi-OliveiraDepartment of Genetics and Evolutionary Biology, Human Genome and Stem Cell Research Center, Biosciences Institute, University of São Paulo (USP), São Paulo - SP, 05508-900, Brazil.
Camila Manso MussoDepartment of Genetics and Evolutionary Biology, Human Genome and Stem Cell Research Center, Biosciences Institute, University of São Paulo (USP), São Paulo - SP, 05508-900, Brazil.
Murilo Sena AmaralButantan Institute, São Paulo - SP, 05503-900, Brazil.
Lucas Ferreira daSilvaDepartment of Biochemistry, Institute of Chemistry, University of São Paulo (USP), São Paulo - SP, 05508-900, Brazil.
Renato Mancini AstrayButantan Institute, São Paulo - SP, 05503-900, Brazil.
Sandra Fernanda Suárez-PatiñoButantan Institute, São Paulo - SP, 05503-900, Brazil.
Daniella Cristina VentiniButantan Institute, São Paulo - SP, 05503-900, Brazil.
Sérgio Gomes da SilvaAlbert Einstein Hospital, São Paulo - SP, 05652-900, Brazil.
Guilherme Lopes YamamotoDepartment of Genetics and Evolutionary Biology, Human Genome and Stem Cell Research Center, Biosciences Institute, University of São Paulo (USP), São Paulo - SP, 05508-900, Brazil.
Suzana EzquinaDepartment of Genetics and Evolutionary Biology, Human Genome and Stem Cell Research Center, Biosciences Institute, University of São Paulo (USP), São Paulo - SP, 05508-900, Brazil.
Michel Satya NaslavskyDepartment of Genetics and Evolutionary Biology, Human Genome and Stem Cell Research Center, Biosciences Institute, University of São Paulo (USP), São Paulo - SP, 05508-900, Brazil.
Kayque Alves Telles-SilvaDepartment of Genetics and Evolutionary Biology, Human Genome and Stem Cell Research Center, Biosciences Institute, University of São Paulo (USP), São Paulo - SP, 05508-900, Brazil.
Karina WeinmannDepartment of Genetics and Evolutionary Biology, Human Genome and Stem Cell Research Center, Biosciences Institute, University of São Paulo (USP), São Paulo - SP, 05508-900, Brazil.
Vanessa van der LindenAACD, Recife - PE, 50080-810, Brazil.
Helio van der LindenRehabilitation Center-Dr. Henrique Santillo, Goiânia - GO, 74653-230, Brazil.
João Ricardo Mendes de OliveiraNeuropsychiatry Department and KeizoAsami Laboratory, Federal University of Pernambuco (UFPE), Recife - PE, 50670-901, Brazil.
Nivia Maria Rodrigues ArraisDepartment of Pediatrics, Federal University of Rio Grande do Norte (UFRN), Natal- RN, 59010-180, Brazil.
Adriana MeloISEA, Campina Grande- PB, 58400-220, Brazil.
Thalita FigueiredoDepartment of Genetics and Evolutionary Biology, Human Genome and Stem Cell Research Center, Biosciences Institute, University of São Paulo (USP), São Paulo - SP, 05508-900, Brazil.
Silvana SantosDepartment of Biology, Paraíba State University (UEPB), Campina Grande - PB, 58429-500, Brazil.
Joanna Goes Castro MeiraFederal University of Bahia (UFBA), Salvador - BA, 40170-115, Brazil.
Saulo Duarte PassosInfectious pediatric laboratory, Medicine School of Jundiaí, Jundiaí - SP, 13202-550, Brazil.
Roque Pacheco de AlmeidaDivision of Immunology and Molecular Biology Laboratory, Federal University of Sergipe (UFS), Aracaju - SP, 49100-000, Brazil.
Ana Jovina Barreto BispoDivision of Immunology and Molecular Biology Laboratory, Federal University of Sergipe (UFS), Aracaju - SP, 49100-000, Brazil.
Esper Abrão CavalheiroNeuroscience laboratory, Department of Neurology and Neurosurgery, Federal University of São Paulo-UNIFESP/EPM, São Paulo - SP, 04039-002, Brazil.
Jorge KalilButantan Institute, São Paulo - SP, 05503-900, Brazil.
Edécio Cunha-NetoHeart Institute, Faculty of Medicine, University of São Paulo (USP), São Paulo - SP, 05403-900, Brazil.
Helder NakayaDepartment of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo (USP), São Paulo - SP, 05508-900, Brazil.ORCID http://orcid.org/0000-0001-5297-9108
Robert Andreata-SantosVaccine Development Laboratory, Department of Microbiology, Institute of Biomedical Science, University of São Paulo (USP), São Paulo - SP, 05508-900, Brazil.
Luis Carlos de Souza FerreiraVaccine Development Laboratory, Department of Microbiology, Institute of Biomedical Science, University of São Paulo (USP), São Paulo - SP, 05508-900, Brazil.
Sergio Verjovski-AlmeidaButantan Institute, São Paulo - SP, 05503-900, Brazil.ORCID http://orcid.org/0000-0002-6356-2401
Paulo Lee HoButantan Institute, São Paulo - SP, 05503-900, Brazil.
Maria Rita Passos-BuenoDepartment of Genetics and Evolutionary Biology, Human Genome and Stem Cell Research Center, Biosciences Institute, University of São Paulo (USP), São Paulo - SP, 05508-900, Brazil.
Mayana ZatzDepartment of Genetics and Evolutionary Biology, Human Genome and Stem Cell Research Center, Biosciences Institute, University of São Paulo (USP), São Paulo - SP, 05508-900, Brazil. mayazatz@usp.br.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Congenital Zika syndrome (CZS) causes early brain development impairment by affecting neural progenitor cells (NPCs). Here, we analyze NPCs from three pairs of dizygotic twins discordant for CZS. We compare by RNA-Seq the NPCs derived from CZS-affected and CZS-unaffected twins. Prior to Zika virus (ZIKV) infection the NPCs from CZS babies show a significantly different gene expression signature of mTOR and Wnt pathway regulators, key to a neurodevelopmental program. Following ZIKV in vitro infection, cells from affected individuals have significantly higher ZIKV replication and reduced cell growth. Whole-exome analysis in 18 affected CZS babies as compared to 5 unaffected twins and 609 controls excludes a monogenic model to explain resistance or increased susceptibility to CZS development. Overall, our results indicate that CZS is not a stochastic event and depends on NPC intrinsic susceptibility, possibly related to oligogenic and/or epigenetic mechanisms.
Indexed as
Gene ExpressionTwins, DizygoticBrainBrazilCase-Control StudiesFemaleGenetic Predisposition to DiseaseHigh-Throughput Nucleotide SequencingHumansInduced Pluripotent Stem CellsInfantInfant, NewbornMaleNeural Stem CellsSequence Analysis, RNATOR Serine-Threonine KinasesMTOR protein, humanTOR Serine-Threonine Kinases
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