ArticleScientific reports2018
Abnormal cerebellar processing of the neck proprioceptive information drives dysfunctions in cervical dystonia.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 35 citations in OpenAlex.
- Abnormal Connectivity of the Head Neural Integrator in Cervical Dystonia.Movement disorders : official journal of the Movement Disorder Society · 2025Observational
- Convergence of vestibular and proprioceptive signals in the cerebellar nodulus/uvula enhances the encoding of self-motion in primates.Current biology : CB · 2025Article
- Brain network pathophysiology in dystonia.Dystonia (Lausanne, Switzerland) · 2025Article
- A gait-based paradigm to investigate central body representation in cervical dystonia patients.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023Observational
- Dystonia in Childhood: How Insights from Paediatric Research Enrich the Network Theory of Dystonia.Advances in neurobiology · 2023Article
- Contemporary clinical neurophysiology applications in dystonia.Journal of neural transmission (Vienna, Austria : 1996) · 2021Review
- The Forward Model: A Unifying Theory for the Role of the Cerebellum in Motor Control and Sense of Agency.Frontiers in systems neuroscience · 2021Article
- Neurobiological mechanisms associated with antipsychotic drug-induced dystonia.Journal of psychopharmacology (Oxford, England) · 2021Review
- Abnormal microscale neuronal connectivity triggered by a proprioceptive stimulus in dystonia.Scientific reports · 2020Article
- Altered sensory system activity and connectivity patterns in adductor spasmodic dysphonia.Scientific reports · 2020Article
- Consensus Paper: Experimental Neurostimulation of the Cerebellum.Cerebellum (London, England) · 2019Review
- Increased Finger-Tapping Related Cerebellar Activation in Cervical Dystonia, Enhanced by Transcranial Stimulation: An Indicator of Compensation?Frontiers in neurology · 2019Article
- Oscillatory Cortical Activity in an Animal Model of Dystonia Caused by Cerebellar Dysfunction.Frontiers in cellular neuroscience · 2018Article
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10 authors at 4 institutions in 3 countries.
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Abstract
The cerebellum can influence the responsiveness of the primary motor cortex (M1) to undergo spike timing-dependent plastic changes through a complex mechanism involving multiple relays in the cerebello-thalamo-cortical pathway. Previous TMS studies showed that cerebellar cortex excitation can block the increase in M1 excitability induced by a paired-associative stimulation (PAS), while cerebellar cortex inhibition would enhance it. Since cerebellum is known to be affected in many types of dystonia, this bidirectional modulation was assessed in 22 patients with cervical dystonia and 23 healthy controls. Exactly opposite effects were found in patients: cerebellar inhibition suppressed the effects of PAS, while cerebellar excitation enhanced them. Another experiment comparing healthy subjects maintaining the head straight with subjects maintaining the head turned as the patients found that turning the head is enough to invert the cerebellar modulation of M1 plasticity. A third control experiment in healthy subjects showed that proprioceptive perturbation of the sterno-cleido-mastoid muscle had the same effects as turning the head. We discuss these finding in the light of the recent model of a mesencephalic head integrator. We also suggest that abnormal cerebellar processing of the neck proprioceptive information drives dysfunctions of the integrator in cervical dystonia.
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