Evidence map›Paper›PMID 29396200›Full record

ReviewTrends in parasitology2018

Do Cryptic Reservoirs Threaten Gambiense-Sleeping Sickness Elimination?

Informal Expert Group on Gambiense HAT Reservoirs, Philippe Büscher, Jean-Mathieu Bart, Marleen Boelaert, Bruno Bucheton, Giuliano Cecchi, Nakul Chitnis, David Courtin, Luisa M Figueiredo, José-Ramon Franco and 19 more

Abstract readReview
In one paragraph

Review in Trends in parasitology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 94 papers.

0numbers the graph read from it
0cells of the map it votes in
94citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

94 citing papers in PubMed.

  1. Trial
  2. Review
  3. Article
  4. Wildlife surveys detectCurrent research in parasitology & vector-borne diseases · 2026
    Article
  5. Article
  6. Observational
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Observational
  13. Article
  14. The Hidden Hand of Asymptomatic Infection Hinders Control of Neglected Tropical Diseases: A Modeling Analysis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024
    Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article

34 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors.

Informal Expert Group on Gambiense HAT Reservoirs
Philippe BüscherDepartment of Biomedical Sciences, Institute of Tropical Medicine, Nationalestraat 155, 2000 Antwerp, Belgium. Electronic address: pbuscher@itg.be.
Jean-Mathieu BartINTERTRYP, IRD, CIRAD, Univ Montpellier, Montpellier, France; Centro Nacional de Medicina Tropical, Instituto de Salud Carlos III, Calle Sinesio Delgado 4, 28029 Madrid, Spain.
Marleen BoelaertDepartment of Public Health, Institute of Tropical Medicine, Nationalestraat 155, 2000 Antwerp, Belgium.
Bruno BuchetonINTERTRYP, IRD, CIRAD, Univ Montpellier, Montpellier, France.
Giuliano CecchiSub-regional Office for Eastern Africa, Food and Agriculture Organization of the United Nations, CMC Road, Bole Sub City, Kebele 12/13, P O Box 5536, Addis Ababa, Ethiopia.
Nakul ChitnisDepartment of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Socinstrasse 57, Postfach, 4002 Basel, Switzerland; University of Basel, Switzerland.
David CourtinUniversité Paris Descartes, Institut de Recherche pour le Développement, Unité MERIT, Mère et enfant face aux infections tropicales, 4 avenue de l'Observatoire, 75006 Paris, France.
Luisa M FigueiredoInstituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Avenida Prof Egas Moniz, 1649-028 Lisboa, Portugal.
José-Ramon FrancoControl of Neglected Tropical Diseases, Innovative and Intensified Disease Management, World Health Organization, Via Appia 20, 1202 Geneva, Switzerland.
Pascal GrébautINTERTRYP, IRD, CIRAD, Univ Montpellier, Montpellier, France.
Epco HaskerDepartment of Public Health, Institute of Tropical Medicine, Nationalestraat 155, 2000 Antwerp, Belgium.
Hamidou IlboudoInstitut de Recherche sur les Bases Biologiques de la Lutte Intégrée, Centre International de Recherche-Développement sur l'Élevage en zone Subhumide, 01 BP 454 Bobo-Dioulasso 01, Burkina Faso.
Vincent JamonneauINTERTRYP, IRD, CIRAD, Univ Montpellier, Montpellier, France.
Mathurin KoffiUniversité Jean Lorougnon Guédé, BP 150 Daloa, Côte d'Ivoire.
Veerle LejonINTERTRYP, IRD, CIRAD, Univ Montpellier, Montpellier, France.
Annette MacLeodInstitute of Biodiversity, Animal Health and Comparative Medicine, University of Glasgow, Henry Wellcome Building, 464 Bearsden Road, Glasgow, UK.
Justin MasumuDépartement de Parasitologie, Institut National de Recherche Biomédicale, Avenue de la Démocratie, BP 1197 Kinshasa 1, République Démocratique du Congo.
Enock MatovuCollege of Veterinary Medicine, Animal Resources and Biosecurity, Makerere University, P O Box 7062 Kampala, Uganda.
Raffaele MattioliAnimal Production and Health Division, Food and Agriculture Organization of the United Nations, Viale delle Terme di Caracalla, 00153 Rome, Italy.
Harry NoyesInstitute of Integrative Biology, University of Liverpool, Liverpool L69 7ZB, UK.
Albert PicadoFoundation for Innovative New Diagnostics, 9 Chemin des Mines, 1202 Geneva, Switzerland.
Kat S RockZeeman Institute for Systems Biology & Infectious Disease Research, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, UK.
Brice RotureauTrypanosome Transmission Group, Trypanosome Cell Biology Unit, INSERM U1201 and Department of Parasites and Insect Vectors, Institut Pasteur, 25, rue du Docteur Roux, 75015 Paris, France.
Gustave SimoDepartment of Biochemistry, Faculty of Science, University of Dschang, P O Box 67 Dschang, Cameroon.
Sophie ThévenonINTERTRYP, IRD, CIRAD, Univ Montpellier, Montpellier, France; CIRAD, INTERTRYP, Montpellier, France.
Sandra TrindadeInstituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Avenida Prof Egas Moniz, 1649-028 Lisboa, Portugal.
Philippe TrucINTERTRYP, IRD, CIRAD, Univ Montpellier, Montpellier, France.
Nick Van ReetDepartment of Biomedical Sciences, Institute of Tropical Medicine, Nationalestraat 155, 2000 Antwerp, Belgium.

Funding

Wellcome Trust 099310/Z/12/ZWellcome Trust 209511/Z/17/ZWorld Health Organization 001
6 · The paper itself

Abstract

Trypanosoma brucei gambiense causes human African trypanosomiasis (HAT). Between 1990 and 2015, almost 440000 cases were reported. Large-scale screening of populations at risk, drug donations, and efforts by national and international stakeholders have brought the epidemic under control with <2200 cases in 2016. The World Health Organization (WHO) has set the goals of gambiense-HAT elimination as a public health problem for 2020, and of interruption of transmission to humans for 2030. Latent human infections and possible animal reservoirs may challenge these goals. It remains largely unknown whether, and to what extend, they have an impact on gambiense-HAT transmission. We argue that a better understanding of the contribution of human and putative animal reservoirs to gambiense-HAT epidemiology is mandatory to inform elimination strategies.

Indexed as

Disease EradicationDisease ReservoirsAnimalsHumansRisk FactorsTrypanosoma brucei gambienseTrypanosomiasis, Africaneliminationhuman African trypanosomiasisreservoirsleeping sicknesstransmissionTrypanosoma brucei gambiense

Identifiers

PMID29396200
PMCPMC5840517

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.