ReviewTrends in molecular medicine2018
Central and Peripheral Biomarkers of Stress Response for Addiction Risk and Relapse Vulnerability.
Review in Trends in molecular medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
71 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Does Attentional Bias Predict Relapse in Addiction? A Systematic Review of Longitudinal Studies.Brain and behavior · 2025Pooled it
- The brain in social context: A systematic review of substance use and social processing from adolescence to young adulthood.Developmental cognitive neuroscience · 2022Pooled it
- Proposing a "Brain Health Checkup (BHC)" as a Global Potential "Standard of Care" to Overcome Reward Dysregulation in Primary Care Medicine: Coupling Genetic Risk Testing and Induction of "Dopamine Homeostasis".International journal of environmental research and public health · 2022Pooled it
- Effects of the neuroactive steroid precursor pregnenolone on stress- and alcohol cue-provoked pain responses in individuals with alcohol use disorder.Experimental and clinical psychopharmacology · 2026Trial
- Pregnenolone reduces provoked craving and cocaine use in men and women with cocaine use disorder: A pilot trial.Drug and alcohol dependence · 2025Trial
- Pregnenolone effects on parasympathetic response to stress and alcohol cue provocation in treatment-seeking individuals with alcohol use disorder.Alcohol, clinical & experimental research · 2025Trial
- Pregnenolone effects on provoked alcohol craving, anxiety, HPA axis, and autonomic arousal in individuals with alcohol use disorder.Psychopharmacology · 2023Trial
- Pregnenolone Reduces Stress-Induced Craving, Anxiety, and Autonomic Arousal in Individuals with Cocaine Use Disorder.Biomolecules · 2022Trial
- Moderation of Prazosin's Efficacy by Alcohol Withdrawal Symptoms.The American journal of psychiatry · 2021Trial
- Effects of Prazosin on Provoked Alcohol Craving and Autonomic and Neuroendocrine Response to Stress in Alcohol Use Disorder.Alcoholism, clinical and experimental research · 2020Trial
- A role for the right dorsolateral prefrontal cortex in enhancing regulation of both craving and negative emotions in internet gaming disorder: A randomized trial.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2020Trial
- Heterogeneous structural brain signatures of methamphetamine and ketamine use disorders revealed by normative modeling.Molecular psychiatry · 2026Article
- Validation of the Chinese Stress Sensitivity Inventory and Its Association With Internet Gaming Disorder Symptoms.Psychiatry investigation · 2026Article
- Retrospective Cohort Study of The Lovelady Center: A large Faith-Based Residential Recovery Program for Women with Substance Use Disorders in the USA.Journal of religion and health · 2026Article
- A study on the psychometric properties of the Arabic-translated connor-davidson resilience scale (CD-RISC-25) and Arabic-translated stimulant relapse risk scale (SRRS) in Emirati patients with substance use disorder.International journal of mental health systems · 2026Article
- Buprenorphine Microinduction Treatment in Tri-Diagnosis Patients with Opioid Use Disorder and Chronic Non-Cancerous Pain.Current pain and headache reports · 2026Review
- Sex-specific differences in endocannabinoid regulation of cocaine-evoked dopamine in the medial nucleus accumbens shell.bioRxiv : the preprint server for biology · 2026Article
- Exploring gender differences in tobacco cue-induced craving and heart rate variability in individuals with a tobacco use disorder.Drug and alcohol dependence reports · 2026Article
- Augmenting neurocounseling in addiction recovery with intelligent systems: a roadmap for research and practice.Frontiers in psychiatry · 2026Article
- Altered association of plasmatic oxytocin with affective stress response in alcohol use disorder.Translational psychiatry · 2025Article
11 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Substance use disorders (SUDs) are marked by heterogeneity in clinical symptomatology and high relapse rates following treatment. Here, we describe specific peripheral and central stress responses associated with the pathophysiology of SUDs. We outline potential stress response measures, including hypothalamus-pituitary-adrenal axis markers, autonomic responses, and central structural and functional brain alterations that could be exploited as putative biomarkers in SUDs. We posit that stress responses can be predictive of both the development of SUDs and their high relapsing nature. We examine their potential as candidate biomarkers, as well as the remaining challenges in developing and implementing their application for the prevention and treatment of SUDs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.