Evidence map›Paper›PMID 29396145›Full record

ArticleTrends in molecular medicine2018

HDAC5 Regulates the Formation of Drug Memories.

Alexander C W Smith, Paul J Kenny

Open access · greenAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Trends in molecular medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Epigenetic function during heroin self-administration controls future relapse-associated behavior in a cell type-specific manner.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Alexander C W SmithDepartment of Neuroscience, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029-6574, USA.
Paul J KennyDepartment of Neuroscience, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029-6574, USA. Electronic address: paul.kenny@mssm.edu.
Icahn School of Medicine at Mount Sinai · US

Funding

Role of MicroRNAs in the Mechanisms of Drug DependenceR01DA025983 · NIDA · SCRIPPS RESEARCH INSTITUTE, THE · PI KENNY, PAUL J. · 2008 to 2020
$4.0M
Role of microRNA-212 in striatal plasticity underlying cocaine addictionF32DA043315 · NIDA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI SMITH, ALEXANDER WANLESS · 2017 to 2018
$82k
NIDA NIH HHS F32 DA043315NIDA NIH HHS R01 DA025983
6 · The paper itself

Abstract

Cocaine-associated environmental cues can precipitate craving and relapse in addicted individuals even after years of abstinence, but the molecular mechanisms by which maladaptive drug memories are generated remain unclear. New findings suggest that histone deacetylase 5 (HDAC5) plays a key role in this process.

Indexed as

CocaineHistone DeacetylasesHumansMemoryCocaineHDAC5 protein, humanHistone Deacetylases

Identifiers

PMID29396145
PMCPMC12285792
OpenAlexW2786301547

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.