Evidence map›Paper›PMID 29396108›Full record

SynthesisAlzheimer's & dementia : the journal of the Alzheimer's Association2018

Transitions across cognitive states and death among older adults in relation to education: A multistate survival model using data from six longitudinal studies.

Annie Robitaille, Ardo van den Hout, Robson J M Machado, David A Bennett, Iva Čukić, Ian J Deary, Scott M Hofer, Emiel O Hoogendijk, Martijn Huisman, Boo Johansson and 11 more

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  18. The Role of Dementia Diagnostic Delay in the Inverse Cancer-Dementia Association.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Annie RobitailleDepartment of Psychology, University of Victoria, Victoria, BC, Canada. Electronic address: robitaille.annie.2@uqam.ca.
Ardo van den HoutDepartment of Statistical Science, University College London, London, UK.
Robson J M MachadoDepartment of Statistical Science, University College London, London, UK.
David A BennettRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, US.
Iva ČukićDepartment of Psychology, University of Edinburgh, Edinburgh, UK; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
Ian J DearyDepartment of Psychology, University of Edinburgh, Edinburgh, UK; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
Scott M HoferDepartment of Psychology, University of Victoria, Victoria, BC, Canada; Department of Neurology, Oregon Health & Science University, Portland, OR, US.
Emiel O HoogendijkDepartment of Epidemiology and Biostatistics, Amsterdam Public Health Research Institute, VU University Medical Center, Amsterdam, The Netherlands.
Martijn HuismanDepartment of Epidemiology and Biostatistics, Amsterdam Public Health Research Institute, VU University Medical Center, Amsterdam, The Netherlands.
Boo JohanssonDepartment of Psychology and Centre for Health and Ageing AGECAP, University of Gothenburg, Gothenburg, Sweden.
Andriy V KovalDepartment of Psychology, University of Victoria, Victoria, BC, Canada.
Maaike van der NoordtDepartment of Epidemiology and Biostatistics, Amsterdam Public Health Research Institute, VU University Medical Center, Amsterdam, The Netherlands.
Andrea M PiccininDepartment of Psychology, University of Victoria, Victoria, BC, Canada.
Judith J M RijnhartDepartment of Epidemiology and Biostatistics, Amsterdam Public Health Research Institute, VU University Medical Center, Amsterdam, The Netherlands.
Archana Singh-ManouxDepartment of Epidemiology & Public Health, University College London, London, UK; INSERM, U1018, Epidemiology of Ageing & Age-related diseases, Villejuif, France.
Johan SkoogDepartment of Psychology and Centre for Health and Ageing AGECAP, University of Gothenburg, Gothenburg, Sweden.
Ingmar SkoogDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Centre for Health and Ageing AGECAP, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
John StarrCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK; Department of Clinical and Surgical Sciences, Geriatric Medicine Unit, University of Edinburgh, Edinburgh, UK; Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, UK.
Lisa VermuntDepartment of Neurology and Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands.
Sean CloustonProgram in Public Health and Department of Preventive Medicine, Stony Brook University, Stony Brook, New York, US.
Graciela Muniz TerreraDepartment of Psychology, University of Victoria, Victoria, BC, Canada; Centre for Dementia Prevention, The University of Edinburgh, Edinburgh, UK.

Funding

SUPPLEMENT TO RUSH ALZHEIMERS DISEASE CENTER COREP30AG010161 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI LEURGANS, SUE E. · 1991 to 2020
$49.1M
EPIDEMIOLOGY OF NEURAL RESERVE AND NEUROBIOLOGY IN AGINGR01AG017917 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 2001 to 2023
$43.3M
RISK FACTORS, PATHOLOGY, AND CLINICAL EXPRESSIONS OF ADR01AG015819 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 1998 to 2024
$21.4M
Risk Factors for Cognitive Decline in African-AmericansR01AG022018 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BARNES, LISA L · 2004 to 2025
$18.2M
Characterizing the Behavior Profile of Healthy Cognitive AgingR01AG034374 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI PATRICIA A BOYLE · 2009 to 2026
$8.8M
Epidemiologic Study of Impaired Decision-Making in Preclinical Alzheimer's DiseasR01AG033678 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BOYLE, PATRICIA A · 2009 to 2025
$7.8M
Study Coordination and Measurement CoreP01AG043362 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI PICCININ, ANDREA M · 2013 to 2017
$7.8M
Socio-economic status and heterogeneity in agingR01AG013196 · NIA · UNIVERSITY OF LONDON INST OF NEUROLOGY · PI MARMOT, MICHAEL G, SINGH-MANOUX, ARCHANA · 1996 to 2013
$3.5M
Risk Factors and the Neurobiologic Substrate of FrailtyR01AG024480 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BUCHMAN, ARON S · 2005 to 2009
$3.2M
Neurobiologic Study of Psychological Distress & DementiaR01AG024871 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI WILSON, ROBERT S · 2006 to 2010
$1.8M
Genetic Associations with Alzheimer-free SurvivalR01AG026916 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI KRAMER, PATRICIA L · 2005 to 2008
$1.8M
Health behaviors over the adult lifecourse and cognitive agingR01AG034454 · NIA · UNIVERSITY COLLEGE LONDON · PI KIVIMAKI, MIKA J, SINGH-MANOUX, ARCHANA · 2009 to 2013
$1.5M
British Heart Foundation RG/13/2/30098Medical Research Council MR/K013351/1Medical Research Council MR/K026992/1Medical Research Council MR/R024227/1NIA NIH HHS K23 AG023040NIA NIH HHS P01 AG043362NIA NIH HHS P30 AG010161NIA NIH HHS R01 AG013196NIA NIH HHS R01 AG015819NIA NIH HHS R01 AG017917NIA NIH HHS R01 AG022018NIA NIH HHS R01 AG024480NIA NIH HHS R01 AG024871NIA NIH HHS R01 AG026916NIA NIH HHS R01 AG033678NIA NIH HHS R01 AG034374NIA NIH HHS R01 AG034454NIA NIH HHS R21 AG030765
6 · The paper itself

Abstract

introductionThis study examines the role of educational attainment, an indicator of cognitive reserve, on transitions in later life between cognitive states (normal Mini-Mental State Examination (MMSE), mild MMSE impairment, and severe MMSE impairment) and death.

methodsAnalysis of six international longitudinal studies was performed using a coordinated approach. Multistate survival models were used to estimate the transition patterns via different cognitive states. Life expectancies were estimated.

resultsAcross most studies, a higher level of education was associated with a lower risk of transitioning from normal MMSE to mild MMSE impairment but was not associated with other transitions. Those with higher levels of education and socioeconomic status had longer nonimpaired life expectancies. DISCUSSION: This study highlights the importance of education in later life and that early life experiences can delay later compromised cognitive health. This study also demonstrates the feasibility and benefit in conducting coordinated analysis across multiple studies to validate findings.

Indexed as

CognitionEducational StatusAgedAged, 80 and overCognitive AgingCognitive DysfunctionCognitive ReserveDementiaFemaleHumansLongitudinal StudiesMaleMental Status ScheduleProtective FactorsRisk FactorsSurvival AnalysisCognitionDementiaEducationLife expectancyMultistate modelingSocioeconomic status

Identifiers

PMID29396108
PMCPMC6377940

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.