Evidence map›Paper›PMID 29396025›Full record

ArticleJournal of cystic fibrosis : official journal of the European Cystic Fibrosis Society2018

Early life growth patterns persist for 12 years and impact pulmonary outcomes in cystic fibrosis.

Don B Sanders, Zhumin Zhang, Philip M Farrell, HuiChuan J Lai, Wisconsin CF Neonatal Screening Group

Open access · greenAbstract read
In one paragraph

Article in Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
5.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.

  1. Guideline
  2. Article
  3. Impact of Genetics on Endocrine Manifestations of Cystic Fibrosis.Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists · 2026
    Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. Review
  11. Association between insurance variability and early lung function in children with cystic fibrosis.Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2022
    Observational
  12. Impact of guideline-recommended dietitian assessments on weight gain in infants with cystic fibrosis.Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2022
    Observational
  13. A new era for people with cystic fibrosis.European journal of pediatrics · 2021
    Review
  14. Newborn screening alone insufficient to improve pulmonary outcomes for cystic fibrosis.Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2021
    Article
  15. Article
  16. Article
  17. Review
  18. Review
  19. Newborn Screening for CF across the Globe-International journal of neonatal screening · 2020
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Don B SandersDepartment of Pediatrics, 705 Riley Hospital Dr, Suite 4270, Riley Hospital for Children, School of Medicine, Indiana University, Indiana, IN 46202, USA.
Zhumin ZhangDepartment of Nutritional Sciences, 1415 Linden Dr, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53706, USA.
Philip M FarrellDepartment of Pediatrics, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA; Department of Population Health Sciences, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.
HuiChuan J LaiDepartment of Nutritional Sciences, 1415 Linden Dr, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53706, USA; Department of Pediatrics, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA; Department of Population Health Sciences, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA. Electronic address: hlai@wisc.edu.
Wisconsin CF Neonatal Screening Group
University of Wisconsin–Madison · USRiley Hospital for Children · US

Funding

PULMONARY BENEFITS OF CYSTIC FIBROSIS NEONATAL SCREENINGR01DK034108 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI FARRELL, PHILIP M · 1986 to 2011
$6.9M
Newborn Screening, Malnutrition and Lung Disease in Children with Cystic FibrosisR01DK072126 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI LAI, HUICHUAN J · 2006 to 2015
$4.3M
Early Childhood Diet, Growth, Gut Microbiome And Lung Health in Cystic FibrosisR01DK109692 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI LAI, HUICHUAN J · 2016 to 2021
$3.8M
NIDDK NIH HHS R01 DK034108NIDDK NIH HHS R01 DK072126NIDDK NIH HHS R01 DK109692
6 · The paper itself

Abstract

backgroundIn children with cystic fibrosis (CF), recovery from growth faltering within 2 years of diagnosis (Responders) is associated with better growth and less lung disease at age 6 years. This study examined whether these benefits are sustained through 12 years of age.

methodsLongitudinal growth from 76 children with CF enrolled in the Wisconsin CF Neonatal Screening Project was examined and categorized into 5 groups: R

resultsSixty-two percent were Responders. Within this group, 47% were R

conclusionsEarly growth recovery in CF is critical, as malnutrition during infancy tends to persist and catch-up growth after age 2 years is difficult. The longer adequate growth was maintained after early growth recovery, the better the pulmonary outcomes at age 12 years.

Indexed as

Cystic FibrosisExocrine Pancreatic InsufficiencyLungLung DiseasesMeconium IleusAdolescentAge FactorsChildChild, PreschoolGrowth and DevelopmentHumansInfantInfant, NewbornLongitudinal StudiesNeonatal ScreeningRadiography, ThoracicCatch-up growthGrowthGrowth falteringLung diseasePulmonary functionQuantitative chest radiography

Identifiers

PMID29396025
PMCPMC6026029
OpenAlexW2787646439

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.