Evidence map›Paper›PMID 29395990›Full record

ReviewThe Lancet. Neurology2018

Diagnosis and management of Duchenne muscular dystrophy, part 2: respiratory, cardiac, bone health, and orthopaedic management.

David J Birnkrant, Katharine Bushby, Carla M Bann, Benjamin A Alman, Susan D Apkon, Angela Blackwell, Laura E Case, Linda Cripe, Stasia Hadjiyannakis, Aaron K Olson and 5 more

4 registry-linked trialsAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The Lancet. Neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 544 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
544citing papers in PubMed, 9 pooled it
38.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03680365 completednot on this map

Your Voice; Impact of DMD. A Qualitative Assessment of the Impact of DMD on the Lives of Families

TypeobservationalSponsorJett Foundation, Inc.Ran2018 to 2019Enrolled60ConditionsDuchenne Muscular Dystrophy, Burden, Dependency, Disability Physical, Disease Management
NCT05029232 naunknown statusnot on this mapstarted 2021, after this paper: background citation

Comprehensive Study of Duchenne Muscular Dystrophy at Sohag University Hospital

TypeinterventionalSponsorSohag UniversityRan2021 to 2023Enrolled50ConditionsDuchenne Muscular DystrophyArmsMLPA for duchenne
NCT05516745 naunknown statusnot on this mapstarted 2021, after this paper: background citation

E-monitoring of Pulmonary Function in Patients With Duchenne Muscular Dystrophy Undergoing Respiratory Rehabilitation at Home"

TypeinterventionalSponsorMedical University of GdanskRan2021 to 2025Enrolled200ConditionsDuchenne Muscular Dystrophy (DMD)ArmsAioCare spirometer, telerehabiliation of the respiratory system
NCT05753462 phase1 / phase2unknown statusnot on this mapstarted 2023, after this paper: background citation

Phase 1/2a, Monocentric, Open Label Study to Evaluate the Safety, PK and PD of SQY51 in Paediatric and Adult Patients With a Genetically Confirmed Diagnosis of Duchenne Muscular Dystrophy

TypeinterventionalSponsorSqy TherapeuticsRan2023 to 2025Enrolled12ConditionsDuchenne Muscular DystrophyArmsPhase 1, SQY51, Phase 2a, SQY51 (cohort 1), Phase 2a, SQY51 (cohort 2), Phase 2a, SQY51 (cohort 3)
3 · Its place in the literature

Who cites it

544 citing papers in PubMed, 9 syntheses or guidelines pooled it, 1,082 citations in OpenAlex.

  1. A systematic review of the frequency of sleep evaluations, sleep disorders, and treatments among individuals with muscular dystrophy.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2026
    Pooled it
  2. Pooled it
  3. Pooled it
  4. Guideline
  5. Exploring the natural history of bone mineral density in Duchenne muscular dystrophy: a systematic literature review.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025
    Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Pooled it
  10. Trial
  11. Trial
  12. Trial
  13. Trial
  14. Trial
  15. Article
  16. Article
  17. [Duchenne muscular dystrophy-associated cardiomyopathy: advances in diagnosis and management].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2026
    Review
  18. Review
  19. Review
  20. Article

484 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 11 institutions in 3 countries.

David J BirnkrantDepartment of Pediatrics, MetroHealth Medical Center, Case Western Reserve University, Cleveland, OH, USA. Electronic address: dbirnkrant@metrohealth.org.
Katharine BushbyJohn Walton Muscular Dystrophy Research Centre, Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, UK.
Carla M BannRTI International, Research Triangle Park, NC, USA.
Benjamin A AlmanDepartment of Orthopaedic Surgery, Duke University School of Medicine and Health System, Durham, NC, USA.
Susan D ApkonDepartment of Rehabilitation Medicine, Seattle Children's Hospital, Seattle, WA, USA.
Angela BlackwellRTI International, Research Triangle Park, NC, USA.
Laura E CaseDoctor of Physical Therapy Division, Department of Orthopaedics, Duke University School of Medicine, Durham, NC, USA.
Linda CripeDepartment of Pediatrics, Nationwide Children's Hospital, The Ohio State University, Columbus, OH, USA.
Stasia HadjiyannakisDivision of Endocrinology and Metabolism, Children's Hospital of Eastern Ontario, and University of Ottawa, Ottawa, ON, Canada.
Aaron K OlsonDepartment of Pediatrics, Seattle Children's Hospital, Seattle, WA, USA.
Daniel W SheehanJohn R Oishei Children's Hospital, University at Buffalo, The State University of New York, Buffalo, NY, USA.
Julie BolenRare Disorders and Health Outcomes Team, National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA, USA.
David R WeberDivision of Endocrinology and Diabetes, Golisano Children's Hospital, University of Rochester Medical Center, Rochester, NY, USA.
Leanne M WardDivision of Endocrinology and Metabolism, Children's Hospital of Eastern Ontario, and University of Ottawa, Ottawa, ON, Canada.
DMD Care Considerations Working Group
Children's Hospital of Eastern Ontario · CARTI International · USSeattle Children's Hospital · USDuke University · USDuke University Health System · USGolisano Children's Hospital · USMetroHealth Medical Center · USNational Center on Birth Defects and Developmental Disabilities · USNewcastle University · GBThe Ohio State University · USWomen & Children's Hospital of Buffalo · US

Funding

Intramural CDC HHS CC999999
6 · The paper itself

Abstract

A coordinated, multidisciplinary approach to care is essential for optimum management of the primary manifestations and secondary complications of Duchenne muscular dystrophy (DMD). Contemporary care has been shaped by the availability of more sensitive diagnostic techniques and the earlier use of therapeutic interventions, which have the potential to improve patients' duration and quality of life. In part 2 of this update of the DMD care considerations, we present the latest recommendations for respiratory, cardiac, bone health and osteoporosis, and orthopaedic and surgical management for boys and men with DMD. Additionally, we provide guidance on cardiac management for female carriers of a disease-causing mutation. The new care considerations acknowledge the effects of long-term glucocorticoid use on the natural history of DMD, and the need for care guidance across the lifespan as patients live longer. The management of DMD looks set to change substantially as new genetic and molecular therapies become available.

Indexed as

Quality of LifeBone and BonesCardiovascular SystemHumansMuscular Dystrophy, DuchenneRespiratory System

Identifiers

PMID29395990
PMCPMC5889091
OpenAlexW2784812244

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.