ArticleCurrent biology : CB2018
Modulation of Host Learning in Aedes aegypti Mosquitoes.
Article in Current biology : CB, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
43 citing papers in PubMed, 104 citations in OpenAlex.
- Sexually Dimorphic Visual Processing in the Yellow-Fever Mosquito,bioRxiv : the preprint server for biology · 2026Article
- Bioamine disruption leads to memory deficits in the whip spider, Phrynus marginemaculatus.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2026Article
- Simultaneous recording of spikes and calcium signals in odor-evoked responses ofJournal of neurogenetics · 2025Article
- Context-dependent effects of carbon dioxide on cross-modal integration during mosquito flight.Scientific reports · 2025Article
- Divergence and Parallelism in Two Tropical Drosophilids Simultaneously Invading a Desert Environment.Genome biology and evolution · 2025Article
- The sensory arsenal mosquitoes use to find us.Trends in parasitology · 2025Review
- The potential impacts of vector host species fidelity on zoonotic arbovirus transmission.PLoS neglected tropical diseases · 2025Article
- Making scents of mosquito repellents.Trends in parasitology · 2025Review
- Genome Editing in the Yellow Fever Mosquito Aedes aegypti using CRISPR-Cas9.Journal of visualized experiments : JoVE · 2025Article
- Sensory appendage protein triggers alarm to pyrethroid in Indian malarial vector Anopheles culicifacies.PloS one · 2025Article
- Rhythms in insect olfactory systems: underlying mechanisms and outstanding questions.The Journal of experimental biology · 2024Review
- Hydrophobic solution functions as a multifaceted mosquito repellent by enhancing chemical transfer, altering object tracking, and forming aversive memory.Scientific reports · 2024Article
- A cell atlas of the larval Aedes aegypti ventral nerve cord.Neural development · 2024Article
- The role of Culex territans mosquitoes in the transmission of Batrachochytrium dendrobatidis to amphibian hosts.Parasites & vectors · 2023Article
- Sleep: An Essential and Understudied Process in the Biology of Blood-Feeding Arthropods.Integrative and comparative biology · 2023Review
- Effect of Temperature on Mosquito Olfaction.Integrative and comparative biology · 2023Article
- Combinatorial encoding of odors in the mosquito antennal lobe.Nature communications · 2023Article
- Soap application alters mosquito-host interactions.iScience · 2023Article
- Effect of temperature on mosquito olfaction.bioRxiv : the preprint server for biology · 2023Article
- Technological advances in mosquito olfaction neurogenetics.Trends in genetics : TIG · 2023Review
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9 authors at 3 institutions in 1 country.
Funding
Abstract
How mosquitoes determine which individuals to bite has important epidemiological consequences. This choice is not random; most mosquitoes specialize in one or a few vertebrate host species, and some individuals in a host population are preferred over others. Mosquitoes will also blood feed from other hosts when their preferred is no longer abundant, but the mechanisms mediating these shifts between hosts, and preferences for certain individuals within a host species, remain unclear. Here, we show that olfactory learning may contribute to Aedes aegypti mosquito biting preferences and host shifts. Training and testing to scents of humans and other host species showed that mosquitoes can aversively learn the scent of specific humans and single odorants and learn to avoid the scent of rats (but not chickens). Using pharmacological interventions, RNAi, and CRISPR gene editing, we found that modification of the dopamine-1 receptor suppressed their learning abilities. We further show through combined electrophysiological and behavioral recordings from tethered flying mosquitoes that these odors evoke changes in both behavior and antennal lobe (AL) neuronal responses and that dopamine strongly modulates odor-evoked responses in AL neurons. Not only do these results provide direct experimental evidence that olfactory learning in mosquitoes can play an epidemiological role, but collectively, they also provide neuroanatomical and functional demonstration of the role of dopamine in mediating this learning-induced plasticity, for the first time in a disease vector insect.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.