ArticleNeuron2018
Differing Strategies Despite Shared Lineages of Motor Neurons and Glia to Achieve Robust Development of an Adult Neuropil in Drosophila.
Article in Neuron, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 53 citations in OpenAlex.
- Written in the Stars: Astrocyte Biology From Evolution to Disease.Acta physiologica (Oxford, England) · 2026Review
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- Glia Preserve Their Own Functions While Compensating for Neighboring Glial Cell Dysfunction.Glia · 2025Article
- Cell cycle-dependent cues regulate temporal patterning of thebioRxiv : the preprint server for biology · 2025Article
- Decoding neuronal wiring by joint inference of cell identity and synaptic connectivity.bioRxiv : the preprint server for biology · 2025Article
- Molecular profiling of invertebrate glia.Glia · 2025Review
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- Drosophila glia take shape to sculpt the nervous system.Current opinion in neurobiology · 2023Review
- Astrocyte heterogeneity and interactions with local neural circuits.Essays in biochemistry · 2023Article
- Mechanisms of robustness in gene regulatory networks involved in neural development.Frontiers in molecular neuroscience · 2023Review
- Astrocyte development-More questions than answers.Frontiers in cell and developmental biology · 2023Review
- Serotonergic neuron ribosomal proteins regulate the neuroendocrine control of Drosophila development.PLoS genetics · 2022Article
- Post-transcriptional regulation of transcription factor codes in immature neurons drives neuronal diversity.Cell reports · 2022Article
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- A single-cell transcriptomic atlas of the adulteLife · 2020Article
- Cortical astrocytes develop in a plastic manner at both clonal and cellular levels.Nature communications · 2019Article
- The development and assembly of the Drosophila adult ventral nerve cord.Current opinion in neurobiology · 2019Review
- Stereotyped terminal axon branching of leg motor neurons mediated by IgSF proteins DIP-α and Dpr10.eLife · 2019Article
- Illumination of neural development byCell regeneration (London, England) · 2018Review
- Visualize Drosophila Leg Motor Neuron Axons Through the Adult Cuticle.Journal of visualized experiments : JoVE · 2018Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
In vertebrates and invertebrates, neurons and glia are generated in a stereotyped manner from neural stem cells, but the purpose of invariant lineages is not understood. We show that two stem cells that produce leg motor neurons in Drosophila also generate neuropil glia, which wrap and send processes into the neuropil where motor neuron dendrites arborize. The development of the neuropil glia and leg motor neurons is highly coordinated. However, although motor neurons have a stereotyped birth order and transcription factor code, the number and individual morphologies of the glia born from these lineages are highly plastic, yet the final structure they contribute to is highly stereotyped. We suggest that the shared lineages of these two cell types facilitate the assembly of complex neural circuits and that the two birth order strategies-hardwired for motor neurons and flexible for glia-are important for robust nervous system development, homeostasis, and evolution.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.