Evidence map›Paper›PMID 29395809›Full record

ArticleDiabetes & metabolism2019

Metabolomics signatures associated with an oral glucose challenge in pregnant women.

B Gelaye, C B Clish, M Denis, G Larrabure, M G Tadesse, A Deik, K Pierce, K Bullock, C Dennis, D A Enquobahrie and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diabetes & metabolism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Regulation of maternal-fetal metabolic communication.Cellular and molecular life sciences : CMLS · 2021
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

B GelayeDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, 677, Huntington Avenue, K505F, 02115 Boston, MA, USA; Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA. Electronic address: bgelaye@hsph.harvard.edu.
C B ClishBroad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA.
M DenisUMR amélioration génétique et adaptation des plantes méditerranéennes et tropicales, CIRAD, Montpellier, France.
G LarrabureInstituto Nacional Materno Perinatal de Lima, Lima, Peru; Departamentos de Medicina y Ginecología y Obstetricia Universidad Nacional Mayor de San Marcos, Lima, Peru.
M G TadesseDepartment of Mathematics and Statistics, Georgetown University, Washington DC, USA.
A DeikBroad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA.
K PierceBroad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA.
K BullockBroad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA.
C DennisBroad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA.
D A EnquobahrieDepartment of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA; Center for Perinatal Studies, Swedish Medical Center, Seattle, WA, USA.
M A WilliamsDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, 677, Huntington Avenue, K505F, 02115 Boston, MA, USA.

Funding

ROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Elizabeth Austen Lawson, Takara Leah Stanley · 1994 to 2026
$31.6M
University of Washington MHIRT Training Program GrantT37MD001449 · NIMHD · UNIVERSITY OF WASHINGTON · PI WILLIAMS, MICHELLE A. · 2005 to 2018
$3.5M
NIDDK NIH HHS P30 DK040561NIMHD NIH HHS T37 MD001449
6 · The paper itself

Abstract

aimThe oral glucose tolerance test (OGTT), widely used as a gold standard for gestational diabetes mellitus (GDM) diagnosis, provides a broad view of glucose pathophysiology in response to a glucose challenge. We conducted the present study to evaluate metabolite changes before and after an oral glucose challenge in pregnancy; and to examine the extent to which metabolites may serve to predict GDM diagnosis in pregnant women.

methodsPeruvian pregnant women (n=100) attending prenatal clinics (mean gestation 25 weeks) participated in the study with 23% of them having GDM diagnosis. Serum samples were collected immediately prior to and 2-hours after administration of a 75-g OGTT. Targeted metabolic profiling was performed using a LC-MS based metabolomics platform. Changes in metabolite levels were evaluated using paired Student's t-tests and the change patterns were examined at the level of pathways. Multivariate regression procedures were used to examine metabolite pairwise differences associated with subsequent GDM diagnosis.

resultsOf the 306 metabolites detected, the relative concentration of 127 metabolites were statistically significantly increased or decreased 2-hours after the oral glucose load (false discovery rate [FDR] corrected P-value<0.001). We identified relative decreases in metabolites in acylcarnitines, fatty acids, and diacylglycerols while relative increases were noted among bile acids. In addition, we found that C58:10 triacylglycerol (β=-0.08, SE=0.04), C58:9 triacylglycerol (β=-0.07, SE=0.03), adenosine (β=0.70, SE=0.32), methionine sulfoxide (β=0.36, SE=0.13) were significantly associated with GDM diagnosis even after adjusting for age and body mass index.

conclusionsWe identified alterations in maternal serum metabolites, representing distinct cellular and metabolic pathways including fatty acid metabolism, in response to an oral glucose challenge. These findings offer novel perspectives on the pathophysiological mechanisms underlying GDM.

Indexed as

Blood GlucoseMetabolomicsAdolescentAdultBile Acids and SaltsCarnitineDiabetes, GestationalDiglyceridesFatty AcidsFemaleGlucoseGlucose Tolerance TestHumansLipid MetabolismPregnancyYoung AdultacylcarnitineBile Acids and SaltsBlood GlucoseCarnitineDiglyceridesFatty AcidsGlucoseGDMMetabolomicsOGTTOmics

Identifiers

PMID29395809
PMCPMC6041194

What OpenQuestion holds

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LicenceTDM
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.