Evidence map›Paper›PMID 29395627›Full record

ReviewInternational journal of radiation oncology, biology, physics2018

Challenges and Promises of PET Radiomics.

Gary J R Cook, Gurdip Azad, Kasia Owczarczyk, Musib Siddique, Vicky Goh

Registry-linked trialAbstract readReview
In one paragraph

Review in International journal of radiation oncology, biology, physics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04276025 (Relationship Between Histopathological Features, Mutation Status, 18F-FDG PET/CT Radiomic Imaging Parameters as Well as Clinical Outcome in Patients With Treatment-naïve Non-small Cell Lung Cancer), which is not on this map. Cited by 81 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
81citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04276025 completednot on this map

Relationship Between Histopathological Features, Mutation Status, 18F-FDG PET/CT Radiomic Imaging Parameters as Well as Clinical Outcome in Patients With Treatment-naïve Non-small Cell Lung Cancer

TypeobservationalSponsorKlinikum Bayreuth GmbHRan2016 to 2020Enrolled2,000ConditionsNSCLCArmsClinical routine F18-FDG-PET/CT, molecular pathology and clinical outcome
3 · Its place in the literature

Who cites it

81 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Guideline
  2. Pooled it
  3. Trial
  4. Trial
  5. Predicting locally advanced rectal cancer response to neoadjuvant therapy withEuropean journal of nuclear medicine and molecular imaging · 2019
    Trial
  6. Article
  7. Article
  8. Review
  9. Article
  10. Future of radiotheranostics.BMJ oncology · 2026
    Review
  11. Current Uses for Medical Imaging With Orthopaedic Implant Technology.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2026
    Review
  12. The study of dual-phaseScientific reports · 2025
    Article
  13. Review
  14. Article
  15. Article
  16. Long-axial field-of-view PET/CT improves radiomics feature reliability.European journal of nuclear medicine and molecular imaging · 2025
    Article
  17. Review
  18. Review
  19. Article
  20. Article

21 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Gary J R CookDepartment of Cancer Imaging, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom. Electronic address: gary.cook@kcl.ac.uk.
Gurdip AzadDepartment of Cancer Imaging, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom.
Kasia OwczarczykDepartment of Cancer Imaging, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom.
Musib SiddiqueDepartment of Cancer Imaging, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom.
Vicky GohDepartment of Cancer Imaging, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom.

Funding

Cancer Research UK 16463Cancer Research UK 20000Cancer Research UK C1519/A16463Department of HealthMedical Research CouncilWellcome TrustWellcome Trust WT203148/Z/16/Z
6 · The paper itself

Abstract

purposeRadiomics describes the extraction of multiple, otherwise invisible, features from medical images that, with bioinformatic approaches, can be used to provide additional information that can predict underlying tumor biology and behavior. METHODS AND MATERIALS: Radiomic signatures can be used alone or with other patient-specific data to improve tumor phenotyping, treatment response prediction, and prognosis, noninvasively. The data describing

resultsIn relation to radiation therapy practice, early data have reported the use of radiomic approaches to better define tumor volumes and predict radiation toxicity and treatment response.

conclusionsAlthough at an early stage of development, with many technical challenges remaining and a need for standardization, promise nevertheless exists that PET radiomics will contribute to personalized medicine, especially with the availability of increased computing power and the development of machine-learning approaches for imaging.

Indexed as

Positron-Emission TomographyHumansImage Processing, Computer-AssistedRadiotherapy

Identifiers

PMID29395627
PMCPMC6278749

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.